Author

T. Beuming

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:deep learning· 2 Research Focus:drug response / drug discovery· 2 Assay:protein structure· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Approach:experimental assay· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

A. M. Diaz-Rovira· 2 shared H. Martin· 2 shared L. Diaz· 2 shared S. S. Ray· 2 shared V. Guallar· 2 shared A. Chow· 1 shared A. Rizzi· 1 shared A. Schurer· 1 shared

Activity by Year

2019-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersBiochemistry

A. M. Diaz-Rovira

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Author profile →

3 papers

Recent·Most cited

Are Deep Learning Structural Models Sufficiently Accurate for Virtual Screening? Application of Docking Algorithms to AlphaFold2 Predicted Structures

A. M. Diaz-Rovira, H. Martin, T. Beuming, L. Diaz, V. Guallar, S. S. Ray

This study evaluates the accuracy of AlphaFold2 structures for virtual screening, finding that out-of-the-box models are insufficient for hit-finding in low sequence identity targets and suggest post-processing improvements.

bioRxiv · Aug 18, 2022Biochemistry

Are Deep Learning Structural Models Sufficiently Accurate for Free Energy Calculations? Application of FEP+ to AlphaFold2 Predicted Structures

T. Beuming, H. Martin, A. M. Diaz-Rovira, L. Diaz, V. Guallar, S. S. Ray

The paper assesses if AlphaFold2 structures are accurate enough for FEP calculations in drug discovery, finding they perform comparably to X-ray structures in most cases.

bioRxiv · Aug 16, 2022Biochemistry

Small-molecule targeting of MUSASHI RNA-binding activity in acute myeloid leukemia

G. Minuesa, S. K. Albanese, A. Chow, A. Schurer, S.-M. Park, C. Z. Rotsides, J. Taggart, A. Rizzi, L. N. Naden, T. Chou, S. Gourkanti, D. Cappel, M. C. Passarelli, L. Fairchild, C. Adura, , M. G. Kharas

This study identifies Ro 08-2750 as a small molecule that targets MSI2 RNA-binding activity, inducing differentiation, apoptosis, and reduced disease burden in AML models.

Nature Communications · Jun 19, 2019Peer-reviewedCancer Biology