Excitatory neuron-specific suppression of the integrated stress response pathway contributes to autism-related phenotypes in a mouse model of fragile X syndrome
M. Hooshmandi, V. Sharma, C. T. Perez, R. Sood, K. Simbriger, C. Wong, K. C. Lister, A. U. Guzman, T. D. Bartley, C. Rocha, G. Maussion, E. Nadler, P. M. Roque, I. Gantois, J. Popic, , A. Khoutorsky
The paper shows that suppressing the ISR pathway in excitatory neurons of FXS mice leads to autism-like behaviors and that restoring it rescues these phenotypes.
bioRxiv · Apr 24, 2023 · PreprintNeuroscience