R. Sood

Organ specific microenvironmental MR1 expression in cutaneous melanoma

The paper examines organ-specific microenvironmental MR1 expression in cutaneous melanoma using zebrafish models and imaging techniques, finding differential immune responses and metabolism in brain versus skeletal metastases.

Macrophage mediated mesoscale brain mechanical homeostasis mechanically imaged via optical tweezers and Brillouin microscopy in vivo

The paper uses optical tweezers and Brillouin microscopy to study brain mechanical properties in larval zebrafish, showing macrophages influence tissue mechanics during development.

Unraveling molecular basis for reduced neuraminidase inhibitors susceptibility in highly pathogenic avian influenza A (H5N1) viruses isolated from chickens in India

This study identifies mutations in H5N1 avian influenza viruses that confer resistance to neuraminidase inhibitors, revealing their molecular mechanisms and implications for antiviral strategies.

Excitatory neuron-specific suppression of the integrated stress response pathway contributes to autism-related phenotypes in a mouse model of fragile X syndrome

The paper shows that suppressing the ISR pathway in excitatory neurons of FXS mice leads to autism-like behaviors and that restoring it rescues these phenotypes.

A novel fluorobenzothiazole RBx 10080758 as a dual inhibitor against bacterial GyraseB (GyrB) and Topoisomerase IV (parE) of Gram-positive pathogens causing skin and respiratory infections

This paper evaluates a novel fluorobenzothiazole inhibitor, RBx 10080758, showing potent in vitro and in vivo activity against drug-resistant Gram-positive bacteria by dual targeting Gyrase B and Topoisomerase IV.

p53 mutation in normal esophagus promotes multiple stages of carcinogenesis but is constrained by clonal competition

This study shows p53 mutations in normal esophagus drive clonal expansion but are constrained by clonal competition, and LOH is critical for malignant transformation.

Platinum-Induced Mitochondrial OXPHOS Contributes to Cancer Stem Cell Enrichment in Ovarian Cancer

This study shows platinum treatment increases mitochondrial activity and OXPHOS in ovarian cancer cells, leading to enrichment of cancer stem cells, which can be blocked by OXPHOS inhibitors.

Precancer: Mutant clones in normal epithelium outcompete and eliminate esophageal micro-tumors

The paper shows that mutant clones in normal epithelium outcompete and eliminate esophageal micro-tumors through cell competition, preventing tumor formation.

Notch1 mutation drives clonal expansion in normal esophageal epithelium but impairs tumor growth

The paper shows NOTCH1 mutations promote clonal expansion in normal esophageal epithelium but hinder tumor growth, suggesting NOTCH1 inhibition could prevent esophageal squamous cancer.

Combined epigenetic and metabolic inhibition blocks platinum-induced ovarian cancer stem cell enrichment

This study shows that combining DNMT and NAMPT inhibitors with platinum reduces OCSCs and tumorigenesis in ovarian cancer.

Cocculus hirsutus -derived phytopharmaceutical drug has potent anti-dengue activity

This paper identifies Cocculus hirsutus-derived AQCH as a potent anti-dengue drug with in vitro and in vivo efficacy, characterized by five chemical markers and formulated into tablets for further development.

The Endothelial Protein C Receptor plays an essential role in the maintenance of Pregnancy

This study shows that maternal thrombophilia, specifically through EPCR deficiency, leads to placental abruption and severe pregnancy complications, with potential therapeutic targets in thrombin-mediated platelet activation.

Tissue architectural cues drive organ targeting of human tumor cells in zebrafish

The paper shows human tumor cells preferentially colonize specific tissues in zebrafish based on vessel topography and integrin expression, revealing mechanisms of metastatic organ targeting.