C. Wong

Genome assembly of the rare and endangered Grantham's camellia, Camellia granthamiana

This paper presents a chromosome-scale genome assembly of the rare Camellia granthamiana using PacBio and Omni-C data, providing a resource for conservation and phylogenetic studies.

Organ specific microenvironmental MR1 expression in cutaneous melanoma

The paper examines organ-specific microenvironmental MR1 expression in cutaneous melanoma using zebrafish models and imaging techniques, finding differential immune responses and metabolism in brain versus skeletal metastases.

Serine synthesis pathway upregulated by E-cadherin is essential for the proliferation and metastasis of breast cancers

This study shows that E-cadherin upregulates the serine synthesis pathway in breast cancer cells, supporting proliferation and metastasis by providing metabolic precursors and resistance to oxidative stress.

Excitatory neuron-specific suppression of the integrated stress response pathway contributes to autism-related phenotypes in a mouse model of fragile X syndrome

The paper shows that suppressing the ISR pathway in excitatory neurons of FXS mice leads to autism-like behaviors and that restoring it rescues these phenotypes.

ADO-MEDIATED SYNTHESIS OF TAURINE ALTERS THE CHROMATIN LANDSCAPE OF INGUINAL ADIPOSE TISSUE TO ENHANCE NON-SHIVERING THERMOGENESIS

This study shows taurine biosynthesis via ADO enhances NST in inguinal adipose tissue by remodeling chromatin to increase gene transcription for thermogenesis.

TRPM5+ microvillous tuft cells regulate neuroepithelial intrinsic olfactory stem cell proliferation.

The paper identifies TRPM5+ olfactory microvillous cells as tuft cells and shows their role in regulating olfactory stem cell proliferation in response to allergens.

Expression and functional evaluation of recombinant human ABO blood group antigen cleaving glycoside hydrolases α-N-acetylgalactosaminidase, α-galactosidase, and endo-β-galactosidase produced in Escherichia coli

This study evaluates recombinant glycoside hydrolases for converting A, B, and AB blood types to O by cleaving surface antigens, showing partial success in porcine red blood cells.

Semi-field evaluations of three botanically derived repellents against the blacklegged tick, Ixodes scapularis (Acari: Ixodidae)

This study evaluates three botanically-derived repellents against Ixodes scapularis in a semi-field trial, finding they effectively reduce tick attachment compared to controls.

Tuft cell-produced cysteinyl leukotrienes and IL-25 synergistically initiate lung type 2 inflammation

The paper shows that tuft cell-produced cysteinyl leukotrienes and IL-25 synergistically drive lung type 2 inflammation in response to aeroallergens.

CcLBD25 functions as a key regulator of haustorium development in Cuscuta campestris

This study identifies CcLBD25 as a key regulator of haustorium development in Cuscuta campestris, showing its role in pectin digestion and hyphae formation.

Proliferative and quiescent human gastric cancer stem-like cells are associated with differential chemoresistance and patient mortality

This study identifies two stem-like gastric cancer subpopulations with distinct chemoresistance and survival outcomes using scRNA-seq and organoid models.

Tasmanian devil CD28 and CTLA4 capture CD80 and CD86 from adjacent cells

This study shows Tasmanian devil CTLA4 and CD28 can capture CD80 and CD86 from adjacent cells, similar to other species, suggesting potential for checkpoint immunotherapy in divergent species.

Blood cells of adult Drosophila do not expand, but control survival after bacterial infection by induction of Drosocin around their reservoir at the respiratory epithelia

The paper identifies the largest reservoir of blood cells in adult Drosophila and shows they control survival after bacterial infection by inducing Drosocin expression in surrounding tissues.

Excessive ENaC-mediated sodium influx drives NLRP3 inflammasome-dependent autoinflammation in Cystic Fibrosis

This study shows that excessive ENaC-mediated sodium influx drives NLRP3 inflammasome-dependent autoinflammation in Cystic Fibrosis, with potential therapeutic implications for lung inflammation.