Virtual histology of Alzheimer's Disease: why are amyloid-β plaques visible with X-ray phase-contrast imaging?
M. Chourrout, C. Sandt, T. Weitkamp, T. Ducic, D. Meyronet, T. Baron, J. Klohs, N. Rama, H. Boutin, S. Singh, C. Olivier, M. Wiart, E. Brun, S. Bohic, F. Chauveau
This study investigates why amyloid-β plaques in Alzheimer's Disease are visible in X-ray phase-contrast imaging, finding that metal entrapment, not fibrils, drives the contrast in transgenic rodents and human genetic cases.
bioRxiv · Sep 27, 2022Biophysics