Clostridium difficile Toxin B activates the NLRP3 inflammasome in human macrophages, demonstrating a novel regulatory mechanism for the Pyrin inflammasome
M. S. J. Mangan, F. Gorki, K. Krause, A. Heinz, T. Ebert, D. Jahn, K. Hiller, V. Hornung, M. Mauer, F. I. Schmidt, R. Gerhard, E. Latz
The paper shows that C. difficile toxin B activates the NLRP3 inflammasome in human macrophages, not the Pyrin inflammasome, and that Pyrin activation can be restored with prolonged priming.
bioRxiv · Jul 7, 2021 · PreprintImmunology