K. Hiller

Differential cell type-specific function of the aryl hydrocarbon receptor and its repressor in diet-induced obesity and fibrosis

This study investigates the cell type-specific roles of AhR and AhRR in diet-induced obesity and fibrosis, finding that AhRR deficiency protects from metabolic dysfunction and liver damage, while AhR deficiency worsens outcomes.

Anabolic lipid metabolism regulates adipose type 2 innate lymphoid cell differentiation to maintain metabolic health

This study shows that ACC1 regulates adipose ILC2 differentiation and function in obesity, linking lipid metabolism to metabolic health.

Branched chain amino acid synthesis is coupled to TOR activation early in the cell cycle in yeast

The paper shows that branched-chain amino acid synthesis in yeast is linked to TORC1 activation during the G1 phase of the cell cycle.

Non-targeted metabolomics identifies erythronate accumulation in cancer cells

The paper identifies erythronate accumulation in cancer cells using non-targeted metabolomics and suggests it may serve as a cancer biomarker.

Erythritol synthesis in human cells is elevated in response to oxidative stress and regulated by the non-oxidative pentose phosphate pathway

This study identifies that erythritol synthesis in human cells is elevated under oxidative stress and regulated by non-oxidative PPP enzymes.

Clostridium difficile Toxin B activates the NLRP3 inflammasome in human macrophages, demonstrating a novel regulatory mechanism for the Pyrin inflammasome

The paper shows that C. difficile toxin B activates the NLRP3 inflammasome in human macrophages, not the Pyrin inflammasome, and that Pyrin activation can be restored with prolonged priming.

Unraveling the critical growth factors for stable cultivation of (nano-sized) Micrarchaeota

This study reports the enrichment of a stable co-culture of Micrarchaeota with its host and identifies dependencies on host-derived metabolites for growth.