Author

T. Giani

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3

Signature Assays, Organisms & Methods

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Organism:E. coli· 2 Approach:experimental assay· 2 Approach:statistical model· 2 Assay:whole-genome sequencing· 2 Organism:bacteria (other)· 1 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

G. M. Rossolini· 3 shared S. David· 3 shared A. Clements· 2 shared D. M. Aanensen· 2 shared F. Morecchiato· 2 shared G. Frankel· 2 shared J. Sanchez-Garrido· 2 shared W. W. Low· 2 shared

Activity by Year

2019-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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3 shared papersMicrobiology

G. M. Rossolini

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Widespread emergence of OmpK36 loop 3 insertions among multidrug-resistant clones of Klebsiella pneumoniae

S. David, J. Wong, J. Sanchez-Garrido, J. Kwong, W. W. Low, F. Morecchiato, T. Giani, G. M. Rossolini, S. Brett, A. Clements, K. Beis, D. Aanensen, G. Frankel

This study identifies and characterizes OmpK36 loop 3 insertions in Klebsiella pneumoniae, showing their role in carbapenem resistance and clonal spread across different geographic regions.

bioRxiv · Feb 7, 2022Microbiology

Recurrent emergence of carbapenem resistance in Klebsiella pneumoniae mediated by an inhibitory ompK36 mRNA secondary structure

J. L. C. Wong, S. David, J. Sanchez-Garrido, J. Z. Woo, W. W. Low, F. Morecchiato, T. Giani, G. M. Rossolini, S. J. Brett, A. Clements, D. M. Aanensen, S. Rouskin, G. Frankel

This study identifies a synonymous mutation in ompK36 that increases carbapenem resistance in Klebsiella pneumoniae by causing translational suppression.

bioRxiv · Jan 5, 2022Microbiology

Genomic analysis of carbapenemase-encoding plasmids from Klebsiella pneumoniae across Europe highlights three major patterns of dissemination

S. David, V. Cohen, S. Reuter, A. E. Sheppard, T. Giani, J. Parkhill, the European Survey of Carbapenemase-Producing Enterobacteriaceae (EuSCAPE) Working Group, the ESCMID Study Group for Epidemiological Markers (ESGEM), G. M. Rossolini, E. J. Feil, H. Grundmann, D. M. Aanensen

This study analyzes carbapenemase-encoding plasmids in K. pneumoniae across Europe using long-read sequencing, identifying three distinct dissemination patterns of resistance genes.

bioRxiv · Dec 19, 2019 · PreprintMicrobiology