S. David

Structural variants underlie parallel adaptation following global invasion

This study identifies large structural variants as drivers of parallel adaptation in Trifolium repens during global invasion.

Life Identification Numbers: A bacterial strain nomenclature approach

The paper proposes the Life Identification Number (LIN) system as a stable, multilevel strain taxonomy for bacterial pathogens based on core genome MLST to improve epidemiological tracking and nomenclature consistency.

A Quantitative Study of Inappropriate Image Duplication in the Journal Toxicology Reports

This study quantifies image duplication in Toxicology Reports, finding 16% of papers with relevant images contain inappropriate duplications, with AI detection improving identification.

Calcium regulation of the Arabidopsis Na+/K+ transporter HKT1;1 improves seed germination under salt stress

This study shows that calcium regulates HKT1;1 and PP2C49 in Arabidopsis seed germination, improving salt stress tolerance through Na+/K+ homeostasis.

Genomic surveillance of carbapenem-resistant Klebsiella in Wales reveals persistent spread of K. pneumoniae ST307 and adaptive evolution of pOXA-48-like plasmids

This study analyzes Klebsiella isolates from Wales to track the spread of resistant strains and plasmids, identifying ST307 and pOXA-48-like plasmids as key drivers of carbapenem resistance.

Widespread emergence of OmpK36 loop 3 insertions among multidrug-resistant clones of Klebsiella pneumoniae

This study identifies and characterizes OmpK36 loop 3 insertions in Klebsiella pneumoniae, showing their role in carbapenem resistance and clonal spread across different geographic regions.

Recurrent emergence of carbapenem resistance in Klebsiella pneumoniae mediated by an inhibitory ompK36 mRNA secondary structure

This study identifies a synonymous mutation in ompK36 that increases carbapenem resistance in Klebsiella pneumoniae by causing translational suppression.

Altered fibrin clot structure contributes to thrombosis risk in severe COVID-19

The paper shows that altered fibrin clot structure in severe COVID-19 patients contributes to thrombosis risk by forming compact, fibrinolysis-resistant clots.

Neutralising antibodies against the SARS-CoV-2 Delta variant induced by Alhydroxyquim-II-adjuvanted trimeric spike antigens

This study shows that Alhydroxiquim-II-adjuvanted trimeric spike antigens induce high-titre, cross-variant neutralising antibodies against SARS-CoV-2 in animal models.

SIGNR1 promotes immune dysfunction in systemic candidiasis by modulating neutrophil lifespan via T cell-derived histones and G-CSF

This study identifies SIGNR1's role in promoting immune dysfunction during systemic candidiasis by modulating neutrophil lifespan through T cell-derived histones and G-CSF.

One Health or Three? Transmission modelling of Klebsiella isolates reveals ecological barriers to transmission between humans, animals and the environment

This study models Klebsiella transmission across human, animal, and environmental sources, finding limited AMR spread outside clinical settings and human-to-human transmission dominance.

Sterilizing Immunity against SARS-CoV-2 Infection in Mice by a Single-Shot and Modified Imidazoquinoline TLR7/8 Agonist-Adjuvanted Recombinant Spike Protein Vaccine

This paper demonstrates that a novel TLR7/8 agonist adjuvant enables single-shot protection against SARS-CoV-2 and influenza in mice using recombinant spike protein and inactivated vaccines.

Arsenic trioxide resistance in acute promyelocytic leukemia: More to it than PML mutations

This study identifies metabolic rewiring as a mechanism of arsenic trioxide resistance in APL and shows that combining ATO with mitocans can overcome resistance.

Synthetic mycobacterial molecular patterns partially complete Freund's adjuvant

This study identifies synthetic mycobacterial molecular patterns that replicate the adjuvant effect of CFA, offering a defined alternative for immunological research and vaccine development.

Genomic analysis of carbapenemase-encoding plasmids from Klebsiella pneumoniae across Europe highlights three major patterns of dissemination

This study analyzes carbapenemase-encoding plasmids in K. pneumoniae across Europe using long-read sequencing, identifying three distinct dissemination patterns of resistance genes.

Seed predation increases from the Arctic to the Equator and from high to low elevations

The paper finds that post-dispersal seed predation increases from the Arctic to the Equator and from high to low elevations, driven by climate seasonality rather than productivity or biodiversity.