J. Weber

ADAR1 Regulates Lipid Remodeling to Dictate Ferroptosis Sensitivity

This study shows ADAR1 protects TNBC cells from ferroptosis by regulating lipid composition, and identifies cobimetinib as a potential therapeutic agent when combined with ADAR1 loss.

Differential response of Senna occidentalis L. to arsenic and cadmium contaminated soil

This study evaluates how Senna occidentalis responds to arsenic and cadmium contamination, finding arsenic more toxic and leading to greater biomass reduction and stress indicators.

Drug Discovery in Low Data Regimes: Leveraging a Computational Pipeline for the Discovery of Novel SARS-CoV-2 Nsp14-MTase Inhibitors

This paper introduces a computational pipeline for identifying SARS-CoV-2 nsp14 inhibitors using virtual screening, identifying seven candidates including NSC620333 and SS148, with experimental validation of binding affinity and structural insights.

The Arabidopsis U1 snRNP regulates mRNA 3'-end processing

This study identifies U1 snRNP-associated proteins in Arabidopsis and shows their role in regulating mRNA 3'-end processing through premature cleavage and alternative polyadenylation site selection.

CARs are organized in nanodomains in the plasma membrane of T cells that accumulate at tumor contact sites

This study uses super-resolution microscopy to show CARs form nanodomains on T-cell membranes, accumulating at tumor sites, with transposon-engineered CARs showing higher density and faster anti-tumor activity.

A planar-polarized MYO6-DOCK7-RAC1 axis promotes tissue fluidification in mammary epithelia

The paper identifies a MYO6-DOCK7-RAC1 axis that restricts RAC1 activity in a planar polarized manner to drive tissue fluidification and collective motion in carcinoma cell monolayers.

Functional synapses between small cell lung cancer and glutamatergic neurons

This study identifies glutamatergic synaptic interactions between SCLC cells and neurons, showing that these interactions support tumor growth and can be targeted therapeutically.

HIV-1 infection reduces NAD capping of host cell snRNA and snoRNA

This study shows HIV-1 infection reduces NAD capping of host snRNA and snoRNA, leading to increased HIV-1 infectivity by destabilizing RNA duplexes.

Cas12a2 elicits abortive infection via RNA-triggered destruction of double-stranded DNA

This study shows that Cas12a2 causes abortive infection by degrading double-stranded DNA through RNA-triggered activity, and demonstrates its use as an RNA detection tool.

TDP-43 oligomerization and RNA binding are codependent but their loss elicits distinct pathologies

This study shows TDP-43 oligomerization and RNA binding work together to control its stability and localization, and their loss leads to different pathological outcomes.

Arabidopsis PFA-DSP-type phosphohydrolases target specific inositol pyrophosphate messengers

This study identifies Arabidopsis PFA-DSP proteins as specific inositol pyrophosphate phosphohydrolases, revealing their role in regulating these signaling molecules.

Simultaneous assessment of eight phosphorylated STAT residues in T-cells by flow cytometry.

The paper develops a flow cytometry panel to assess eight phosphorylated STAT residues in human T-cells and identifies novel patterns of pSTAT induction in response to stimuli.

Biogenesis of hepatitis B virus e antigen is driven by translocon-associated protein complex and regulated by conserved cysteines in signal peptide

The paper investigates the biogenesis of HBV e antigen, showing TRAP promotes its ER translocation and conserved cysteines regulate signal peptide cleavage and subcellular distribution.

Transient receptor vanilloid 4 (TRPV4) channels are essential for alveolar epithelial cell function

This study shows TRPV4 channels protect alveolar epithelial barriers by maintaining AQP-5 and pSP-C expression, preventing edema during ischemia-reperfusion.

Epicuticular wax lipid composition of endemic European Betula species and its application to chemotaxonomy and paleobotany

This study differentiates four European birch species using epicuticular wax lipid composition, showing potential for chemotaxonomy and paleobotanical applications.

ThX - A next-generation probe for the early detection of amyloid aggregates

This paper introduces ThX, a new fluorescent probe for detecting amyloid aggregates, showing improved brightness and binding affinity over ThT.

Host sex and genotype modify the gut microbiome response to helminth infection

The paper shows that host sex and genotype influence the gut microbiome response to helminth infection in fish.

Photoacoustic molecular rulers based on DNA nanostructures

This paper demonstrates the use of photoacoustic tomography to measure distance-dependent FRET in DNA nanostructures at centimeter depths, validating their potential to enhance photoacoustic signal generation.

The role of gene expression in the recent evolution of resistance in a model host parasite system

This study compares gene expression in two stickleback populations differing in resistance to a parasite, identifying immune-related genes and coexpression networks associated with resistance mechanisms.