Author

T. J. Cui

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 4

Signature Assays, Organisms & Methods

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Assay:imaging· 2 Research Focus:protein folding & dynamics· 2 Organism:bacteria (other)· 1 Approach:deep learning· 1 Research Focus:dimensionality reduction· 1 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1

Frequent Co-Authors

C. Joo· 4 shared J. Hegge· 2 shared J. van der Oost· 2 shared M. Depken· 2 shared M. Klein· 2 shared A. Ananth· 1 shared C. S. Smith· 1 shared I. J. MacRae· 1 shared

Activity by Year

2019-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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4 shared papersBiophysics

C. Joo

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4 papers

Recent·Most cited

Drift correction in localization microscopy using entropy minimization

J. Cnossen, T. J. Cui, C. Joo, C. S. Smith

This paper introduces an entropy minimization method to improve drift correction in localization microscopy, achieving 5x better precision than existing methods without fiducial markers.

bioRxiv · Mar 30, 2021Biophysics

Skipping and sliding to optimize target search on protein-bound DNA and RNA

M. Klein, T. J. Cui, I. J. MacRae, C. Joo, M. Depken

The paper shows that skipping and sliding motions allow searchers to maintain search speed on crowded nucleic-acid substrates, as demonstrated by analyzing human and bacterial Argonaute proteins.

bioRxiv · Jun 4, 2020 · PreprintBiophysics

High-Speed Super-Resolution Imaging Using Protein-Assisted DNA-PAINT

M. Filius, T. J. Cui, A. Ananth, M. Docter, J. Hegge, J. van der Oost, C. Joo

This paper introduces Ago-PAINT, a method that accelerates DNA-PAINT imaging by using Argonaute protein to enhance imager strand binding, achieving 10x faster acquisition without compromising resolution.

Nano Letters · Mar 13, 2020Peer-reviewedBiophysics

Argonaute bypasses cellular obstacles without hindrance during target search

T. J. Cui, M. Klein, J. Hegge, S. D. Chandradoss, J. van der Oost, M. Depken, C. Joo

This study shows Argonaute proteins efficiently search for targets by gliding over secondary structures and bypassing protein barriers through lateral diffusion and intersegmental jumps.

bioRxiv · Jan 30, 2019Biophysics