Genome-wide imaging screen uncovers molecular determinants of arsenite-induced protein aggregation and toxicity and an important role for transcriptional and translational control
S. Andersson, A. Romero, J. I. Rodrigues, S. Hua, X. Hao, T. Jacobson, V. Karl, N. Becker, A. Ashouri, T. Nyström, B. Liu, M. J. Tamas
The paper identifies molecular factors involved in arsenite-induced protein aggregation and toxicity using a genome-wide imaging screen in yeast, showing the importance of transcriptional and translational control in proteostasis.
bioRxiv · Dec 16, 2020Cell Biology