X. Hao

FLASH radiotherapy using high-energy X-rays: validation of the FLASH effect triggered by a compact single high-energy X-ray source device

This study validates the FLASH effect using a compact high-energy X-ray source in mice, showing protective effects on normal tissues but no significant tumor response differences between FLASH and conventional radiotherapy.

Protective Effect of 2-Hydroxyestrone and2-Hydroxyestradiol Against Chemically-Induced Hepatotoxicity In Vitro and In Vivo

This study shows that 2-hydroxyestrone and 2-hydroxyestradiol protect against ferroptosis in hepatoma cells and acetaminophen-induced liver injury by inhibiting PDI activity and reducing NO, ROS, and lipid-ROS accumulation.

Single cell profiling of bone metastasis ecosystems from multiple cancer types reveals convergent and divergent mechanisms of bone colonization.

The paper analyzes bone metastases from six cancer types using single-cell RNA-seq to identify three immune archetypes and their mechanisms of bone colonization.

Unbiased metastatic niche-labeling identifies estrogen receptor-positive macrophages as a barrier of T cell infiltration during bone colonization

CBP/P300 BRD Inhibition Reduces Neutrophil Accumulation and Activates Antitumor Immunity in TNBC

CBP/P300 BRD inhibition reduces neutrophil accumulation and enhances antitumor immunity in neutrophil-enriched TNBC, improving responses to standard therapies.

Harnessing molecular mechanism for precision medicine in dilated cardiomyopathy caused by a mutation in troponin T

This study connects genotype, phenotype, and drug response in dilated cardiomyopathy using molecular mechanism-based computational and experimental approaches for a troponin T mutation.

Maturation and detoxification of synphilin-1 inclusion bodies regulated by sphingolipids

The paper identifies sphingolipids as regulators of synphilin-1 inclusion body maturation and detoxification in yeast and mammalian cells.

Benchmarking nearest neighbor retrieval of zebra finch vocalizations across development

This study benchmarks nearest neighbor retrieval for zebra finch vocalizations, finding high performance in adults but lower in juveniles, with improved results using fixed-size templates and Spearman distance.

Experimental study of modified human tendon stem cells to promote graft ligamentation and tendon-bone healing after anterior cruciate ligament reconstruction

This study modifies human tendon stem cells to enhance graft ligamentation and tendon-bone healing after ACL reconstruction, showing improved recovery in animal models.

A Host-Harbored Metabolic Susceptibility of Coronavirus Enables Broad-Spectrum Targeting

The paper identifies a host metabolic pathway essential for coronavirus replication and shows that inhibiting it with Propranolol has broad antiviral effects.

A non-invasive, fast on/off 'Odourgenetic' Method to Manipulate Physiology

This paper introduces an Odourgenetic method using Drosophila odorant receptors to non-invasively and rapidly manipulate cellular functions and behavior through inhalation of 2-pentanone.

A novel method revealing animal evolutionary relationships based on milk Mid-infrared

This study uses mid-infrared spectra of milk to establish models for assessing mammalian evolutionary relationships and genetic distances with high accuracy.

Extracting extended vocal units from two neighborhoods in the embedding plane

The paper introduces a semi-supervised method to segment and cluster vocalizations by identifying two density-based regions in low-dimensional embeddings, achieving lower false positive error rates.

Imprinted SARS-CoV-2 humoral immunity induces convergent Omicron RBD evolution

The paper shows that convergent evolution of Omicron variants evades antibodies from BA.5 infections while maintaining ACE2 binding, driven by immune imprinting.

The tea plant (Camellia sinensis) FLOWERING LOCUS C-like gene CsFLC1 is correlated with bud dormancy and triggers early flowering in Arabidopsis

The study identifies CsFLC1 in tea plants, showing it influences flowering and bud dormancy, and demonstrates its function in Arabidopsis by promoting early flowering and affecting gene expression related to flowering and hormone pathways.

A small-molecule lycorine derivative protects from obesity by targeting Na+/K+-ATPase α3 independent of food intake suppression

The paper identifies HLY72, a small-molecule derivative of lycorine, as an anti-obesity agent that targets Na+/K+-ATPase α3 in the brain, promoting lipolysis and thermogenesis without affecting food intake.

Further humoral immunity evasion of emerging SARS-CoV-2 BA.4 and BA.5 subvariants

This study shows that BA.4.6, BA.4.7, and BA.5.9 subvariants with R346 mutations evade humoral immunity more effectively than BA.4/BA.5, reducing neutralization titers by 1.5-2.6-fold.

Rational identification of potent and broad sarbecovirus-neutralizing antibody cocktails from SARS convalescents

The paper identifies a potent and broad sarbecovirus-neutralizing antibody cocktail, SA55+SA58, from SARS convalescents to combat Omicron variants and other fast-evolving viruses.

Characterizations of enhanced infectivity and antibody evasion of Omicron BA.2.75

This study characterizes the enhanced infectivity and antibody evasion properties of the SARS-CoV-2 Omicron subvariant BA.2.75 compared to BA.5 and other variants.

Accurate background reduction in adaptive optical 3D-STED nanoscopy by dynamic phase switching

This paper introduces a method to improve signal-to-background ratio in 3D-STED nanoscopy using dynamic phase switching with adaptive optics.

Reduced Neutralization of SARS-CoV-2 Omicron Variant in Sera from SARS-CoV-1 Survivors after 3-dose of Vaccination

This study shows that SARS-CoV-1 survivors vaccinated with ZF2001 have reduced neutralization against SARS-CoV-2 Omicron compared to other variants.

Deformable Mirror based Optimal PSF Engineering for 3D Super-resolution Imaging

This paper develops a framework for generating device-specific optimal PSFs for 3D super-resolution imaging using deformable mirrors, demonstrating superior performance over conventional PSFs.

BA.2.12.1, BA.4 and BA.5 escape antibodies elicited by Omicron infection

This study investigates antibody evasion by SARS-CoV-2 Omicron sublineages BA.2.12.1, BA.4, and BA.5 against plasma from vaccination and BA.1 infection, showing increased neutralization escape.

Artificial Hsp100-mediated systems for re-localizing protein aggregates

This study constructs Hsp100-based systems in yeast to re-localize protein aggregates, showing they can be targeted to daughter cells and organelles without affecting lifespan or toxicity.

Structure and function of diadenylate cyclase DacM from Mycoplasma ovipneumoniae

This study identifies and characterizes DacM, a diadenylate cyclase in Mycoplasma ovipneumoniae that produces c-di-AMP, and presents its crystal structures to inform drug design.

Omicron BA.2 specifically evades broad sarbecovirus neutralizing antibodies

This study shows that BA.2 causes stronger antibody evasion than BA.1, particularly in SARS convalescents, and identifies key mutations responsible for this escape.

Impact of various vaccine boosters on neutralization against Omicron following prime vaccinations with inactivated or adenovirus-vectored vaccine

This study evaluates the effectiveness of various vaccine boosters against the Omicron variant following prime vaccinations with inactivated or adenovirus-vectored vaccines, finding that certain boosters significantly enhance neutralizing activity.

Omicron escapes the majority of existing SARS-CoV-2 neutralizing antibodies

This study identifies how Omicron evades neutralizing antibodies by analyzing mutations and their effects on different epitope groups, showing over 85% of tested antibodies are escaped.

Consistent predictors of microbial community composition across scales in grasslands reveal low context-dependency

The paper identifies consistent predictors of microbial community composition across grassland scales, finding low context-dependency and predictable variation linked to productivity.

Ameliorating Emotional Attention through Modulation of Neural Oscillations with Transcranial Alternating Current Stimulation

This study tests the effect of transcranial alternating current stimulation (tACS) on emotional attention, finding increased alpha power and improved ERP responses in the active group.