S. Hua

PI3K/mTOR is a therapeutically targetable genetic dependency in diffuse intrinsic pontine glioma

This study identifies PI3K/mTOR as a targetable genetic dependency in DIPG and demonstrates that combining paxalisib with metformin improves survival in xenograft models.

CAMSAP-driven microtubule release from γ-TuRC and its regulation by nucleation-promoting factors

This study investigates how CAMSAP proteins and CDK5RAP2 regulate microtubule release from γ-TuRC, revealing their roles in microtubule nucleation and stabilization.

Microtubule plus-end regulation by centriolar cap proteins

The paper investigates how CP110 and CEP97 regulate microtubule plus-end dynamics and centriole biogenesis through direct interactions and synergistic effects.

Scrutiny of human lung infection by SARS-CoV-2 and associated human immune responses in humanized mice

This study shows that humanized mice can be infected by SARS-CoV-2, leading to immune responses and immunopathology, providing a model for studying the virus and testing therapies.

Genome-wide imaging screen uncovers molecular determinants of arsenite-induced protein aggregation and toxicity and an important role for transcriptional and translational control

The paper identifies molecular factors involved in arsenite-induced protein aggregation and toxicity using a genome-wide imaging screen in yeast, showing the importance of transcriptional and translational control in proteostasis.

Skin protective effects of RM191A, a novel superoxide dismutase mimetic

This study evaluates RM191A, a novel SOD mimetic, showing enhanced antioxidant activity and protective effects against UV-induced DNA damage and inflammation in skin models.