T. Krell

Bacterial sensor evolved by decreasing complexity

This study shows how a bacterial chemoreceptor evolved from a bimodular to a monomodular domain by losing one module, revealing that reducing complexity may be a common evolutionary trend in sensory domains.

Differential CheR affinity for chemoreceptor C-terminal pentapeptides biases chemotactic responses

This study shows that variation in C-terminal pentapeptide sequences of chemoreceptors affects CheR affinity, thereby influencing chemotactic responses in Pectobacterium atrosepticum.

Ubiquitous purine sensor modulates diverse signal transduction pathways in bacteria

The paper identifies a purine-binding motif in bacterial receptors and demonstrates its role in modulating second messenger signaling.

Amine recognizing domain in diverse receptors from bacteria and archaea evolved from the universal amino acid sensor

The paper identifies a sequence motif specific for amine-sensing domains in bacterial and archaeal receptors, showing their evolution from a universal amino acid sensor and enabling functional studies of regulatory systems.

Systematic mapping of chemoreceptor specificities for Pseudomonas aeruginosa

This paper systematically identifies and characterizes chemoeffectors for Pseudomonas aeruginosa using a combination of in vivo and in vitro methods.

Amino acid sensor conserved from bacteria to humans

The paper identifies a conserved amino acid recognition motif in dCache_1 domains across species, showing it binds amino acids in bacteria and human calcium channels involved in pain and neurodevelopmental disorders.