J. Xing

Bacterial sensor evolved by decreasing complexity

This study shows how a bacterial chemoreceptor evolved from a bimodular to a monomodular domain by losing one module, revealing that reducing complexity may be a common evolutionary trend in sensory domains.

FKBP11 targeted plasma cells promote abdominal aortic aneurysm progression through an m6A-dependent mechanism

This study identifies FKBP11's role in AAA progression via m6A-dependent mechanisms using multi-omics and machine learning.

NK Cell Exhaustion in Wilson's Disease Revealed by Single-cell RNA Sequencing Predicts the Prognosis of Cholecystitis

This study uses single-cell RNA sequencing to show NK cell exhaustion in Wilson's disease is linked to worse cholecystitis outcomes.

Structural basis for molecular assembly of fucoxanthin chlorophyll a/c-binding proteins in a diatom photosystem I supercomplex

The paper determines the cryo-EM structure of a diatom PSI-FCPI supercomplex, identifies FCPI subunits, and reveals protein-protein interactions and evolutionary conservation of binding motifs.

Synthetic bacterial consortium for degradation of plastic pyrolysis oil waste

This paper develops a synthetic bacterial consortium to degrade plastic pyrolysis oil waste, achieving high removal efficiencies for alkanes and aromatic hydrocarbons, and uses a neural network to model microbial activity.

Multiplexed DNA-PAINT Imaging of the Heterogeneity of Late Endosome/Lysosome Protein Composition

This study uses multiplexed DNA-PAINT imaging to reveal cell-type specific subpopulations of late endosomes/lysosomes with unique protein compositions.

Control of ciliary transcriptional programs during spermatogenesis by antagonistic transcription factors

This study identifies XAP5 and XAP5L as antagonistic transcription factors that regulate ciliary gene expression during spermatogenesis, with XAP5 promoting and XAP5L inhibiting ciliary transcription factors at different stages.

An ancient transcription activator is required for the multiciliogenesis program

This study identifies Edf1 as an essential transcription activator for multiciliogenesis, showing its role in ciliary gene expression and its impact on hydrocephalus in mice.

Nuclear cytoophidia assembly represses transcriptional activity to control skeletal development and homeostasis

This study identifies nuclear cytoophidia as regulators of Impdh2 transcriptional activity, impacting skeletal development and homeostasis through effects on endochondral ossification and osteoclast function.

Graph-Dynamo: Learning stochastic cellular state transition dynamics from single cell data

This paper introduces Graph-Dynamo, a framework that learns stochastic cellular state transition dynamics from single cell data using graph-based methods and Fokker-Planck equations.

Inflammation-Induced Claudin-2 Upregulation Limits Pancreatitis Progression by Enhancing Tight Junction-Controlled Pancreatic Ductal Transport

This study shows CLDN2 upregulation during pancreatitis limits disease progression by enhancing tight junction-controlled fluid transport in pancreatic ductal epithelium.

Origin and functional diversification of PAS domain, a ubiquitous intracellular sensor

The paper investigates the origin and functional diversity of PAS domains across species, identifying their bacterial origin and functional adaptations in different lineages.

Prokaryotic microbial diversity analysis and metabolic function prediction of salt lakes on the Qinghai-Tibet Plateau

This study analyzes microbial diversity and metabolic functions in two salt lakes on the Qinghai-Tibet Plateau using metagenomics, revealing differences in microbial composition and salinity adaptation strategies.

Mosaic-PICASSO: accurate crosstalk removal for multiplex fluorescence imaging

The paper identifies a limitation in mutual information-based demixing for ultra-multiplexed fluorescence imaging and proposes a method to improve accuracy by selecting regions with low spatial similarity.

Dynamical modeling reveals RNA decay mediates the effect of matrix stiffness on aged muscle stem cell fate

This study shows that matrix stiffness affects aged muscle stem cell self-renewal through RNA decay dynamics, which can be modulated by young matrix environments.

Tumor removal limits prostate cancer cell dissemination in bone and osteoblasts induce cancer cell dormancy through focal adhesion kinase

This study shows that tumor removal increases prostate cancer cell dissemination to bones, while osteoblasts induce dormancy through focal adhesion kinase inhibition.

A 4-bp natural deletion of maize Na+/H+ exchanger gene alters maize salt stress tolerance

This paper identifies a 4-bp deletion in the maize ZmSOS1 gene that causes salt sensitivity and develops a molecular marker to improve salt tolerance in breeding programs.

Re-emergence of Severe Acute Diarrhea Syndrome Coronavirus (SADS-CoV) in Guangxi, China, 2021

The paper identifies the re-emergence of SADS-CoV in pigs in Guangxi, China, through qPCR and metagenomic analysis, suggesting undetected circulation since 2019.

STAYGREEN-mediated chlorophyll a catabolism is critical for photosystem stability upon heat stress in ryegrass

This study shows that suppressing Chl a catabolism in ryegrass reduces heat tolerance by disrupting photosystem stability, ROS balance, and chloroplast structure under moderate heat stress.

The Magnaporthe oryzae MAP kinase Pmk1 regulates polycomb repressive complex 2 to reprogram genes expression for biotrophic growth

This paper identifies PRC2-mediated epigenetic repression as critical for regulating gene expression during biotrophic growth in M. oryzae, with Pmk1 coordinating this process by modulating Suz12.

IHR-PVS National Bridging Workshops, a tool to operationalize the collaboration between human and animal health while advancing sector-specific goals in countries

The paper describes the development of IHR-PVS National Bridging Workshops to enhance collaboration between human and animal health sectors through structured, outcome-oriented processes.

Epithelial-to-mesenchymal transition proceeds through directional destabilization of multidimensional attractor

The paper uses time-lapse imaging to study EMT in human cells, revealing two distinct transition paths through a multidimensional feature space.

Prognostic value of Red Blood Cell Distribution Width in Acute Kidney Injury Patients:A Systematic Review and Meta-analysis

This meta-analysis evaluates the prognostic value of Red Blood Cell Distribution Width (RDW) in Acute Kidney Injury (AKI) patients, finding a significant association but noting limitations due to small sample sizes.

Pharmacokinetics Modeling and Simulation of Voriconazole Dosing and Safety in Patients with Liver Cirrhosis

This study models voriconazole pharmacokinetics in cirrhotic patients and recommends reduced dosing for Child-Pugh C patients to improve safety.

A lysosomal dimmer switch regulates cellular quiescence depth

This study identifies lysosomal function as a regulator of cellular quiescence depth, showing it acts like a dimmer switch to modulate quiescence and link it to senescence and aging.