Author

T. Leon

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1 Assay:metabolomics· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

A. Trinquand· 1 shared C. Ryan· 1 shared C. Tudose· 1 shared G. Oliviero· 1 shared J. Bond· 1 shared K. Wynne· 1 shared L. Jones· 1 shared M. Mansour· 1 shared

Activity by Year

2023-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperCancer Biology

A. Trinquand

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1 paper

Recent·Most cited

Loss of Polycomb Repressive Complex 2 function causes asparaginase resistance in T-acute lymphoblastic leukemia through decreased WNT pathway activity

T. Lefeivre, C. Tudose, T.-I. Grosu, L. Jones, T. Leon, K. Wynne, G. Oliviero, O. Smith, A. Trinquand, M. Mansour, C. Ryan, J. Bond

The paper identifies that PRC2 loss in T-ALL reduces WNT pathway activity, leading to asparaginase resistance, which can be overcome by proteasome inhibition.

bioRxiv · Aug 4, 2023 · PreprintCancer Biology