Author

O. Smith

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Evolutionary Biology· 3 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:chromatin & epigenetic regulation· 2 Research Focus:clustering· 2 Research Focus:development & morphogenesis· 2 Research Focus:drug response / drug discovery· 2

Frequent Co-Authors

R. G. Allaby· 2 shared A. Agrawal· 1 shared A. Bhutkar· 1 shared A. Clapham· 1 shared A. Diederichsen· 1 shared A. Duguid· 1 shared A. Jin· 1 shared A. M. Cruz· 1 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 9 mutual co-author links

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Curved chords = mutual co-authorship

2 shared papersEvolutionary Biology

R. G. Allaby

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Loss of Polycomb Repressive Complex 2 function causes asparaginase resistance in T-acute lymphoblastic leukemia through decreased WNT pathway activity

T. Lefeivre, C. Tudose, T.-I. Grosu, L. Jones, T. Leon, K. Wynne, G. Oliviero, O. Smith, A. Trinquand, M. Mansour, C. Ryan, J. Bond

The paper identifies that PRC2 loss in T-ALL reduces WNT pathway activity, leading to asparaginase resistance, which can be overcome by proteasome inhibition.

bioRxiv · Aug 4, 2023 · PreprintCancer Biology

A microRNA expression signature in infant t(4;11) MLL-AF4+ BCP-ALL uncovers novel therapeutic targets

C. Malouf, A. Duguid, G. Camiolo, L. Nitsche, H. Jakobczyk, R. Kotecha, R. Anderson, N. Barrett, O. Smith, K. Ottersbach

This study identifies three microRNAs downregulated in MLL-AF4+ BCP-ALL and shows that targeting their downstream genes with existing drugs reduces leukemia burden.

bioRxiv · Jan 12, 2023 · PreprintCancer Biology

Mismatch repair deficiency is not sufficient to increase tumor immunogenicity

P. M. K. Westcott, F. Muyas, O. Smith, H. Hauck, N. J. Sacks, Z. A. Ely, A. M. Jaeger, W. M. Rideout, A. Bhutkar, D. Zhang, M. C. Beytagh, D. A. Canner, R. T. Bronson, S. Naranjo, A. Jin, , T. Jacks

This study shows that MMRd in mouse tumor models does not increase immunogenicity or ICB response, due to intratumoral heterogeneity.

bioRxiv · Aug 24, 2021 · PreprintCancer Biology

Ancient microRNA profiles of a 14,300-year-old canid are taxonomically informative and give glimpses into gene regulation from the Pleistocene

B. Fromm, M. Tarbier, O. Smith, L. Dalen, T. M. Gilbert, M. R. Friedlander

The paper analyzes ancient microRNA profiles from a 14,300-year-old canid, showing they are taxonomically informative and provide insights into Pleistocene gene regulation.

bioRxiv · Dec 16, 2019Evolutionary Biology

Functional characterization and lineage analysis of broadly neutralizing human antibodies against dengue virus identified by single B cell transcriptomics

N. D. Durham, A. Agrawal, E. Waltari, D. Croote, F. Zanini, M. Fouch, E. Davidson, O. Smith, E. Carabajal, J. E. Pak, B. J. Doranz, M. Robinson, A. M. Sanz, L. L. Albornoz, F. Rosso, , L. Goo

The paper identifies two broadly neutralizing antibodies against dengue virus through single B cell transcriptomics and characterizes their epitopes and evolutionary pathways.

bioRxiv · Oct 2, 2019Microbiology

Flax latitudinal adaptation at LuTFL1 altered architecture and promoted fiber production.

R. Gutaker, M. Zaidem, Y.-B. Fu, A. Diederichsen, O. Smith, R. Ware, R. G. Allaby

The paper shows that LuTFL1 alleles from northern wild flax populations were selected in cultivated flax, altering plant architecture and promoting fiber production through effects on flowering time and morphology.

bioRxiv · Sep 21, 2018Evolutionary Biology

A domestication history of dynamic adaptation and genomic deterioration in sorghum

O. Smith, W. V. Nicholson, L. Kistler, E. Mace, A. Clapham, P. Rose, C. Stevens, R. L. Ware, S. Samavedam, G. Barker, D. Jordan, D. Q. Fuller, R. G. Allaby

This study analyzes archaeogenomes of sorghum to show a decline in genetic diversity and mutation load over time, with dynamic selection pressures and introgression shaping domestication.

bioRxiv · Jun 3, 2018Evolutionary Biology