L. Jones

Loss of Polycomb Repressive Complex 2 function causes asparaginase resistance in T-acute lymphoblastic leukemia through decreased WNT pathway activity

The paper identifies that PRC2 loss in T-ALL reduces WNT pathway activity, leading to asparaginase resistance, which can be overcome by proteasome inhibition.

Cancer drug sensitivity prediction from routine histology images

This paper demonstrates using deep learning to predict cancer drug sensitivity from histology images and cell line data, identifying histological patterns linked to drug responses.

A Human Breast Cell Atlas Mapping the Homeostatic Cellular Shifts in the Adult Breast

This study creates a Human Breast Cell Atlas using scRNA-seq from 55 donors, identifying 41 cell subclusters and showing how factors like age and BRCA mutations affect breast homeostasis and immune cell states.

Data-Driven Modelling of Gene Expression States in Breast Cancer and their Prediction from Routine Whole Slide Images

The paper predicts gene expression states from whole slide images using a graph neural network and identifies co-expressing gene groups with clinical and therapeutic relevance.

Blind spots on western blots: a meta-research study highlighting opportunities to improve figures and methods reporting

This paper analyzes western blot practices in top neuroscience and cell biology journals, finding widespread issues with image display and methods reporting, and provides tools to improve transparency and reproducibility.

Inhibition of mutant IDH1 promotes cycling of acute myeloid leukemia stem cells

This study shows that inhibiting mutant IDH1 in AML promotes leukemic stem cell cycling and sensitizes the disease to azacitidine, suggesting a combination therapy approach.

Multiomic Immunophenotyping of COVID-19 Patients Reveals Early Infection Trajectories

This study integrates multi-omic data from COVID-19 patients to identify immune response patterns linked to disease severity.

Assessing temperature-dependent competition between two invasive mosquito species

This study assesses temperature-dependent competition between Aedes aegypti and Anopheles stephensi, finding Ae. aegypti dominates due to higher larval survival and growth rates across temperatures.

Microclimate and larval habitat density predict adult Aedes albopictus abundance in urban areas

Hookworm-derived small molecule extracts suppress pathology in a mouse model of colitis and inhibit secretion of key inflammatory cytokines in primary human leukocytes

This study identifies anti-inflammatory small molecules from hookworms that reduce colitis pathology in mice and inhibit cytokine secretion in human leukocytes.

Macrophage-mediated immunoediting drives ductal carcinoma evolution: Space is the game changer

This study uses immunohistochemistry data to model how macrophages influence tumor evolution through spatial dynamics and immune escape strategies in ductal carcinomas.

RelTime relaxes the strict molecular clock throughout the phylogeny

This paper clarifies that RelTime does not enforce a strict molecular clock, and discusses the impact of rate equality options and prior assumptions on divergence time estimation.

Mineral analysis of complete dog and cat foods in the UK and compliance with European guidelines

The paper analyzes mineral content in UK dog and cat foods, finding widespread non-compliance with EU guidelines and potential health risks.