PhysiologyeLifePeer-reviewed
Genetic code expansion, click chemistry, and light-activated PI3K reveal details of membrane protein trafficking downstream of receptor tyrosine kinases
D.-S. Koh, A. Stratiievska, S. Jana…·S. E. Gordon
The paper uses optogenetic PI3K activation and genetic code expansion to study RTK signaling, showing PI3K alone can traffic TRPV1 and insulin receptors to the plasma membrane.
DOI 10.7554/elife.91012.3