Conserved loop of a phase modifier endows protein condensates with fluidity
H. Kawamukai, M. Matsusaki, T. Tanimoto, M. Watabe, K. Morishima, S. Tomita, Y. Shinkai, T. Niwa, T. Mannen, H. Kumeta, H. Nanaura, K. Kato, T. Mabuchi, Y. Aiba, T. Uehara, , T. Saio
This study identifies Kapβ2 as a target of DPRs, showing how DPR binding alters its phase-modifying function, leading to toxic RBP condensates in ALS models.
bioRxiv · Jul 3, 2024 · PreprintBiochemistry