E. Mori

Conserved loop of a phase modifier endows protein condensates with fluidity

This study identifies Kapβ2 as a target of DPRs, showing how DPR binding alters its phase-modifying function, leading to toxic RBP condensates in ALS models.

Zinc finger domains bind low-complexity domain polymers

This study shows zinc finger domains bind low-complexity domain polymers in a cross-β-dependent manner, suppressing polymer formation and preferentially recognizing polymeric LC domains.

C9orf72- derived proline:arginine poly-dipeptides disturb cytoskeletal architecture

This study investigates how C9orf72-derived PR poly-dipeptides alter cytoskeletal structure and cell mechanics in mammalian cells.

RT-qPCR analyses on the osteogenic differentiation from human iPS cells: An investigation of reference genes

The paper evaluates reference genes for RT-qPCR in osteogenic differentiation of human iPS cells, finding TBP as the most stable and GAPDH/ACTB as unsuitable.

ATR inhibition enhances 5-fluorouracil sensitivity independent of non-homologous end-joining and homologous recombination repair pathway

This study shows that ATR inhibition increases 5-FU sensitivity in cancer cells, independent of DNA repair pathways.

Transiently structured head domains control intermediate filament assembly

This study shows how low complexity head domains transiently form structured β-strand-enriched polymers that influence intermediate filament assembly and cell morphology.

Proteolytic Cleavage by Matriptase Exacerbating Kidney Injury: a Novel Therapeutic Target

This study identifies Matriptase cleavage of Podocin as a mechanism of podocyte injury in CKD, suggesting Matriptase inhibition as a therapeutic strategy.

Human URAT1/SLC22A12 gene promoter is regulated by 27-hydroxycholesterol through estrogen response elements

The paper identifies 27-hydroxycholesterol's role in regulating URAT1/SLC22A12 gene expression through estrogen response elements, linking cholesterol metabolism to serum uric acid levels.

Invasive Siberian chipmunks Eutamias sibiricus in Italy: a socio-ecological analysis indicates that they could, and should, be removed

The paper assesses the feasibility of eradicating invasive Siberian chipmunks in Italy through socio-ecological analysis, finding public support and spatial expansion indicating urgency for removal.