T. Niwa

This study identifies an inter-organ mechanism of idiopathic pulmonary fibrosis (IPF) using a generative computational approach, revealing a liver-lung crosstalk involving kininogen 1 and bradykinin receptor B1.

This paper introduces PETEOS, a method to enrich polypeptidyl-tRNAs for analysis of nascent proteins, and demonstrates its application in identifying proteins and observing translational responses to stress.

The paper shows that nascent peptides with consecutive D/E residues can cause translation discontinuation in eukaryotes, leading to biased amino acid usage in proteomes.

This study optimizes an LNP-mRNA vaccine targeting SARS-CoV-2 RBD by removing reactogenic materials, improving immunogenicity and protection in macaques.

The paper identifies nascent polypeptides as stabilizers of the translating ribosome, preventing elongation abortion by counteracting intrinsic ribosome destabilization sequences.