K. Kato

Mechanism and regulation of cargo entry into the Commander recycling pathway

The paper identifies the mechanism by which SNX17 cargo is selected for entry into the Commander recycling pathway through direct binding to the Retriever sub-complex.

Highly efficient transgenic mouse production using piggyBac and its application to rapid phenotyping at the founder generation

This study improves transgenic mouse production efficiency using piggyBac, enabling phenotyping in the founder generation and demonstrating application with bacterial artificial chromosome transgenes.

Leaf- and diverged shoot meristem programs shape the stem in rice

This study identifies how leaf and shoot meristem gene programs regulate node-internode patterns in rice stems, revealing interactions between KNOX1 and YABBY genes.

Structure of PSI-LHCI from Cyanidium caldarium provides evolutionary insights into conservation and diversity of red-lineage LHCs

The paper determines the structure of PSI-LHCI from Cyanidium caldarium and investigates its evolutionary relationships with other red-lineage LHCs.

UGGT1-mediated reglucosylation of N-glycan competes with ER-associated degradation of unstable and misfolded glycoproteins

This study shows UGGT1 reglucosylation competes with EDEM-mediated degradation of misfolded glycoproteins, influencing ER protein quality control.

Evolution of wheat blast resistance gene Rmg8 accompanied by differentiation of variants recognizing the powdery mildew fungus

The paper traces the evolutionary origin of wheat blast resistance gene Rmg8 and shows its ability to recognize both wheat blast and powdery mildew pathogens.

Effective mechanical potential of cell-cell interaction in tissues harboring cavity and in cell sheet toward morphogenesis

The paper evaluates an image-based method for inferring cell-cell interaction potentials in tissues with cavities and cell sheets, showing it can reproduce morphological structures.

Effective mechanical potential of cell-cell interaction explains three-dimensional morphologies during early embryogenesis

The paper develops a method to infer mechanical forces of cell-cell interactions and shows that quantitative differences in effective pairwise potentials explain morphological differences in early embryos.

Structural basis of EHEP-mediated offense against phlorotannin-induced defense from brown algae to protect akuBGL activity

The paper determines the structures of EHEP and akuBGL to elucidate how EHEP protects akuBGL from phlorotannin inhibition.

ATF4 Expression in Thermogenic Adipocytes is Required for Cold-Induced Thermogenesis in Mice via FGF21-Independent Mechanisms

This study shows ATF4 is essential for cold-induced thermogenesis in mice through amino acid metabolism, independent of FGF21, while FGF21 is not required for thermoregulation.

Structure of the Commander endosomal trafficking complex linked to X-linked intellectual disability/Ritscher-Schinzel syndrome

The paper presents the structural model of the Commander endosomal trafficking complex, identifies disease-causing mutations, and reveals its molecular function in trafficking.

GDF15 Is Required for Cold-Induced Thermogenesis and Contributes to Improve Systemic Metabolic Health Following Loss of OPA1 in Brown Adipocytes

This study identifies GDF15 as a mediator of improved metabolic health and thermogenesis in OPA1-deficient brown adipocytes, showing its role in glucose homeostasis and cold-induced thermogenesis.

A bispecific antibody NXT007 exerts a hemostatic activity in hemophilia A monkeys enough to keep a non-hemophiliac state

This paper reports a bispecific antibody NXT007 that shows improved hemostatic activity in hemophilia A monkeys, equivalent to FVIII levels, with lower dosing requirements and longer intervals.

PNPO-PLP Axis Senses Prolonged Hypoxia by Regulating Lysosomal Activity

The paper identifies the PNPO-PLP axis as a mechanism for sensing prolonged hypoxia by regulating lysosomal activity in macrophages, leading to altered inflammatory responses.

Novel monoclonal antibodies showing broad neutralizing activity for SARS-CoV-2 variants including Omicrons BA.5 and BA.2.75

Orchestration of Proteins in cyanobacterial Circadian Clock System 1

This study reveals that the cyanobacterial circadian clock involves synchronized multiple association-dissociation reactions between Kai proteins, not a single process as previously thought.

Structure of a monomeric photosystem I core associated with iron-stress-induced-A proteins from Anabaena sp. PCC 7120

The paper determines the structure of a monomeric photosystem I core complex with IsiA proteins from Anabaena sp. PCC 7120 under iron deficiency, revealing their role in inhibiting PSI oligomerization.

The double-layered structure of amyloid-β assemblage on GM1-containing membranes catalytically promotes fibrillization

This study identifies a double-layered Aβ structure on GM1 membranes that catalyzes fibril formation without becoming fibrils itself.

Structural insights into an evolutionary turning-point of photosystem I from prokaryotes to eukaryotes

The paper presents a cryo-EM structure of tetrameric PSI from Cyanophora paradoxa, revealing structural differences from cyanobacterial PSI that suggest evolutionary changes in PSI organization.

Appropriate tension sensitivity of α-catenin ensures rounding morphogenesis of epithelial spheroids

This study shows that appropriate tension sensitivity of α-catenin is essential for epithelial cells to form round spheroids through multicellular rearrangement.

Cancer malignancy is correlated with up-regulation of PCYT2-mediated glycerol phosphate modification of α-dystroglycan

This study shows that PCYT2-mediated glycerol phosphate modification of α-dystroglycan correlates with cancer progression and promotes cell migration in colorectal cancer.

Structural basis for the absence of low-energy chlorophylls responsible for photoprotection from a primitive cyanobacterial PSI

The paper solves the structure of a cyanobacterial PSI lacking low-energy chlorophylls, revealing their absence and functional roles in photoprotection and evolution.

Aqueous extract of Phyllanthus niruri protects against severe malaria by blocking erythrocyte invasion and modulating the host immune response

This study shows that Phyllanthus niruri extract reduces malaria parasite numbers by blocking erythrocyte invasion and modulates host immune responses, protecting against cerebral malaria in mice.

Desiccation-induced fibrous condensation of CAHS protein from an anhydrobiotic tardigrade

This study investigates the self-assembling properties of CAHS1 protein from tardigrades under desiccation conditions, showing it forms hydrogels and condensates that may contribute to desiccation tolerance.

High-resolution cryo-EM structure of photosystem II: Effects of electron beam damage

This study presents a high-resolution cryo-EM structure of photosystem II in solution, revealing its physiological state and effects of electron beam damage.

Structural analysis of RIG-I-like receptors reveals ancient rules of engagement between diverse RNA helicases and TRIM ubiquitin ligases

The paper reveals conserved interaction rules between RNA helicases and TRIM E3 ligases in vertebrate innate immunity using cryo-EM and biochemistry.

Marcksl1 modulates endothelial cell mechanoresponse to haemodynamic forces to control blood vessel shape and size

This study shows that Marcksl1 modulates endothelial cell mechanical responses to blood flow, affecting vessel size and shape during angiogenesis.

A high fat containing chicken egg-only diet suppresses fatty liver induced by a lipid-rich methionine and choline deficient diet.

This study compares the effects of a high-fat diet and an egg-only diet on NAFLD development in mice, finding that the egg-only diet suppresses fatty liver.

Characterization of amyloid β fibril formation under microgravity conditions

This study examines amyloid β fibril formation under microgravity conditions on the ISS, finding slower progression and distinct morphologies compared to ground-based experiments.

A Germinal Center-Associated Microenvironmental Signature Reflects Malignant Phenotype and Outcome of Diffuse Large B-cell Lymphoma

The paper identifies a germinal center-associated microenvironmental signature in DLBCL that correlates with prognosis and molecular features, showing its impact on clinical outcomes.