PhysiologybioRxiv
Loss of Carnitine Palmitoyltransferase 1a Reduces Docosahexaenoic Acid-Containing Phospholipids and Drives Sexually Dimorphic Liver Disease in Mice
M. M. Zelows, C. Cady, N. Dharanipragada…·R. N. Helsley
This study shows that liver-specific deletion of CPT1a in mice leads to reduced DHA-containing phospholipids and sexually dimorphic liver disease, with females showing more severe effects.
DOI 10.1016/j.molmet.2023.101815