Author

T. Mikawa

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Biophysics· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell signaling & trafficking· 1 Assay:imaging· 1 Research Focus:protein folding & dynamics· 1 Organism:yeast· 1

Frequent Co-Authors

H. Yagi· 2 shared T. KigawaiD· 2 shared A. Kagawa· 1 shared C. J. Casas· 1 shared E. Nojiri· 1 shared G. Quintero Plancarte· 1 shared H. Ogasa· 1 shared I. Shimada· 1 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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2 shared papersBiochemistry

H. Yagi

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Ipsilateral restriction of chromosome movement along a centrosome, and apical-basal axis during the cell cycle

P. Cai, C. J. Casas, G. Quintero Plancarte, L. L. Hua, T. Mikawa

The paper shows centromeres oscillate within clusters near the centrosome and apical-basal axis without crossing between clusters during the cell cycle.

bioRxiv · Mar 27, 2023Cell Biology

Hyperactivation of L-lactate oxidase by liquid-liquid phase separation

T. Ura, A. Kagawa, H. Yagi, N. Tochio, T. Kigawa, T. Mikawa, K. Shiraki

This study shows that L-lactate oxidase forms liquid droplets that enhance enzyme activity by reducing KM and increasing kcat, representing the first report of increased kcat through droplet formation.

Scientific Reports · Jan 25, 2023Peer-reviewedBiochemistry

Multi-state structure determination and dynamics analysis reveals a new ubiquitin-recognition mechanism in yeast ubiquitin C-terminal hydrolase

M. Okada, Y. Tateishi, E. Nojiri, T. Mikawa, S. Rajesh, H. Ogasa, T. Ueda, H. Yagi, T. Kohno, T. Kigawa, I. Shimada, P. Guentert, Y. Ito, T. Ikeya

The paper develops an NMR method to determine multi-state structures of proteins and applies it to yeast ubiquitin hydrolase 1, revealing dynamic motions critical for ubiquitin recognition and proteolysis.

bioRxiv · Apr 22, 2021 · PreprintBiophysics