P. Cai

Comprehensive Biosynthetic Analysis of Human Microbiome Reveals Diverse Protective Ribosomal Peptides

This study identifies diverse ribosomally synthesized peptides in the human microbiome and shows some inhibit pathogens and reduce inflammation.

Single cell view of tumor microenvironment gradients in pleural mesothelioma

This paper uses single-cell RNA-sequencing to analyze the tumor microenvironment in pleural mesothelioma, identifying gene programs, fetal-like endothelial cells, and a new therapeutic target.

Pf bacteriophages hinder sputum antibiotic diffusion via electrostatic binding

This study shows Pf phages and sputum polymers reduce antibiotic diffusion through electrostatic binding and liquid crystal formation in chronic Pseudomonas aeruginosa infections.

A deep lung cell atlas reveals cytokine-mediated lineage switching of a rare cell progenitor of the human airway epithelium

This study identifies a rare progenitor cell population in the human airway that can differentiate into ionocytes or tuft cells, and shows cytokines can shift their lineage towards tuft cells in asthma and CF.

A novel simian adenovirus vectored COVID-19 vaccine elicits effective mucosal and systemic immunity in mice by intranasal and intramuscular vaccination regimens

This paper evaluates a novel simian adenovirus vectored COVID-19 vaccine, showing that intranasal vaccination induces stronger mucosal immunity while intramuscular vaccination enhances systemic immunity, with combined regimens providing long-term protection.

Ipsilateral restriction of chromosome movement along a centrosome, and apical-basal axis during the cell cycle

The paper shows centromeres oscillate within clusters near the centrosome and apical-basal axis without crossing between clusters during the cell cycle.

Peripheral NOD-like receptor deficient inflammatory macrophages trigger neutrophil infiltration disrupting daytime locomotion

The paper shows that NOD-like receptor-deficient macrophages cause neutrophil infiltration into the brain, disrupting daytime locomotion in zebrafish.

The noncoding RNA PRANCR regulates splicing of Fibronectin-1 to control keratinocyte proliferation and migration

This study identifies PRANCR as a lncRNA that regulates alternative splicing of FN1 to control keratinocyte proliferation and migration.

Functional classification of noncoding RNAs associated with distinct histone modifications by PIRCh-seq

The paper introduces PIRCh-seq to profile chromatin-associated RNAs with histone modifications, identifying functional groups of lncRNAs and allele-specific interactions.

Co-culture of soil biofilm isolates enables the discovery of novel antibiotics

This study discovers two novel antibiotics by co-culturing soil biofilm isolates and analyzing transcriptomic and genomic data.