M. Okada

An engineered ACE2 decoy broadly neutralizes Omicron subvariants and shows therapeutic effect in SARS-CoV-2-infected cynomolgus macaques

This paper shows an engineered ACE2 decoy neutralizes Omicron subvariants and is effective in treating SARS-CoV-2 infection in macaques.

SARS-CoV-2 ORF8 is a viral cytokine regulating immune responses

This study shows that SARS-CoV-2 ORF8 protein acts as a cytokine that promotes lung inflammation and immune dysregulation in COVID-19, suggesting it as a potential therapeutic target.

Landscape of infection enhancing antibodies in COVID-19 and healthy donors

This study identifies infection-enhancing antibodies in COVID-19 patients and healthy donors, finding they are more frequent in patients but also present in healthy individuals.

Sugar chain structure of apolipoprotein B-100 and its role in oxidation

This study determines the structure of oligosaccharides on apoB-100 and finds they do not significantly affect LDL oxidation or adhesion molecule expression in endothelial cells.

Modeling Pulse Dynamics of Juvenile Fish Enables the Short-term Forecasting of Population Dynamics in Japanese Pufferfish: A Latent Variable Approach

This study uses a latent-variable approach to standardize small-scale survey data of juvenile Japanese pufferfish, improving short-term population forecasting accuracy.

Distinct and interchangeable growing patterns in colorectal cancer stem-like cells are regulated by Musashi-1

The paper identifies distinct growth patterns in colorectal cancer stem-like cells and shows Musashi-1 regulates their plasticity and drug resistance.

The SARS-CoV-2 Delta variant is poised to acquire complete resistance to wild-type spike vaccines

The paper shows the Delta variant can escape NTD antibodies and gain infectivity when specific RBD mutations are present, suggesting the need for updated vaccines.

Critical Role for Isoprenoids in Apicoplast Biogenesis by Malaria Parasites

This study identifies a critical role for isoprenoids in apicoplast biogenesis in malaria parasites, showing that IPP and polyprenols are essential for apicoplast membrane fluidity and inheritance.

Src activation in lipid rafts confers epithelial cells with invasive potential to escape from apical extrusion during cell competition

Multi-state structure determination and dynamics analysis reveals a new ubiquitin-recognition mechanism in yeast ubiquitin C-terminal hydrolase

The paper develops an NMR method to determine multi-state structures of proteins and applies it to yeast ubiquitin hydrolase 1, revealing dynamic motions critical for ubiquitin recognition and proteolysis.

An infectivity-enhancing site on the SARS-CoV-2 spike protein is targeted by COVID-19 patient antibodies

This study identifies an NTD site on SARS-CoV-2 spike protein that enhances infectivity when targeted by antibodies, and finds these antibodies are present in hospitalized patients and some uninfected donors.

Adaptive fitness in APC-mutant cells requires chromosome rearrangements

The paper shows that APC-mutant cells gain adaptive fitness through chromosome rearrangements that restore AURKA activity and counteract mitotic defects.

Doxycycline has Distinct Apicoplast-Specific Mechanisms of Antimalarial Activity

This study shows doxycycline kills malaria parasites via apicoplast-specific mechanisms at high concentrations, with distinct metal-dependent and delayed-death effects in different cycles.

CUB domain-containing protein 1 controls HGF responses by integrating Src and Met-STAT3 signaling

This study identifies CDCP1 as a key regulator of HGF signaling by integrating Src and Met-STAT3 pathways, showing its role in cell invasion and renal growth.