Mechanistic Analysis of Riboswitch Ligand Interactions Provides Insights into Pharmacological Control over Gene Expression
S. Parmar, D. D. Bume, C. M. Connelly, R. E. Boer, P. R. Prestwood, Z. Wang, H. Labuhn, K. Sinnadurai, A. Feri, J. Ouellet, P. Homan, T. Numata, J. S. Schneekloth
This study investigates how different small molecules affect riboswitch activity by altering RNA conformation, showing distinct mechanisms in live cells.
bioRxiv · Feb 23, 2024Biochemistry