A. Rahman

The ability of enzymes to preserve reactive conformations with well-positioned residues during enzyme-catalyzed reactions can be an important factor for efficient catalysis: a case study of CARNMT1

This study uses computational simulations to show that preserving reactive conformations with well-positioned residues is critical for catalytic efficiency in CARNMT1, as demonstrated by comparing wild-type and mutant enzymes.

Artemisinin-resistant Plasmodium falciparum Kelch13 mutant proteins display reduced heme-binding affinity and decreased artemisinin activation

This study shows that PfKelch13 mutants have reduced heme-binding affinity, leading to decreased artemisinin activation and contributing to artemisinin resistance.

Alignment Free Phylogeny Construction Using Maximum Likelihood Using k-mer Counts

This paper introduces a model for k-mer frequency change based on a birth-death-migration process to estimate maximum likelihood phylogenies without sequence alignment.

Early life adversity has sex-dependent effects on survival across the lifespan in rhesus macaques

This study examines how early life adversity affects survival in male and female rhesus macaques, finding sex-dependent differences in mortality risk across the lifespan.

HIV-Tocky system to visualize proviral expression dynamics

The paper introduces HIV-Tocky, a reporter system using a fluorescent Timer protein to visualize HIV-1 provirus expression dynamics and identifies two latent subsets of proviruses.

Determining the shelf life of an erythropoietin alfa biosimilar GBPD002 through stability study

This study evaluates the stability of the erythropoietin alfa biosimilar GBPD002 under various environmental conditions and determines its shelf life as 24 months.

Indigenous probiotics Lactobacillus reuteri and Enterococcus faecium exhibit positive growth performance and disease prevention against extended-spectrum cephalosporin and fluoroquinolones resistant Salmonella enterica in broiler chicks.

This study shows that indigenous probiotics Lactobacillus reuteri and Enterococcus faecium improve growth and reduce Salmonella infection in broiler chicks compared to commercial probiotics.

Comparative Phylogenetic Analysis and Transcriptomic Profiling of Dengue (DENV-3 genotype I) Outbreak in 2021 in Bangladesh

This study uses transcriptomic and phylodynamic analyses to characterize DENV-3 genotype I outbreak in Bangladesh, identifying differentially expressed genes and immune-related pathways in dengue patients.

Building bridges from genome to physiology using machine learning and Drosophila experimental evolution

The paper uses machine learning and Drosophila experimental evolution to identify genomic regions causally linked to physiological traits.

Lymphoma cells are circulating in blood of Enzootic Bovine Leukosis and clonality value of virus-infected cells is a useful information for the diagnostic test

The paper demonstrates that clonality values of BLV-infected cells in blood can reliably detect Enzootic Bovine Leukosis and are useful for diagnostic testing.

Actin isovariant ACT7 controls root meristem development in Arabidopsis through modulating auxin and ethylene responses

This study shows that ACT7, an actin isovariant, regulates root meristem development in Arabidopsis by modulating auxin and ethylene responses through PIN1 and PIN2 trafficking.

A conserved Guided Entry of Tail-anchored pathway is involved in the trafficking of tail-anchored membrane proteins in Plasmodium falciparum.

This study identifies the conserved GET pathway components in Plasmodium falciparum and their association with predicted TA proteins, validating the pathway's functional existence in the parasite.

Humans surviving cholera develop antibodies against Vibrio cholerae O-specific polysaccharide that inhibit pathogen motility

This study shows that antibodies against Vibrio cholerae O-specific polysaccharide inhibit bacterial motility and provide protection against cholera in a murine model.

High Cysteinyl Leukotriene Receptor 1 Expression Correlates with Poor Survival of Uveal Melanoma Patients and Cognate Antagonist Drugs Modulate the Growth, Cancer Secretome, and Metabolism of Uveal Melanoma Cells.

This paper shows high CysLT1 receptor expression in uveal melanoma correlates with poor survival and that CysLT1 antagonists inhibit tumor growth and alter cancer secretome and metabolism.

Diverse biological processes coordinate the transcriptional response to nutritional changes in a Drosophila melanogaster multiparent population

The paper identifies diet-induced gene expression variation in Drosophila melanogaster using RNA-seq, revealing diverse pathways beyond the insulin/TOR pathway.

ATP Binding Cassette Proteins ABCG37 and ABCG33 are required for potassium-independent cesium uptake in Arabidopsis roots

This study identifies ABCG33 and ABCG37 as potassium-independent cesium uptake facilitators in Arabidopsis roots through genetic and physiological analyses.

PIN FORMED 2 facilitates the transport of Arsenite in Arabidopsis thaliana

This study shows PIN2 facilitates arsenite transport in Arabidopsis, leading to arsenite accumulation and root growth inhibition.

Inhibition of ErbB kinase signalling promotes resolution of neutrophilic inflammation

The paper identifies ErbB kinase inhibitors as potential therapies for neutrophilic inflammation by showing they accelerate neutrophil apoptosis in multiple models.

A Modified Injector and Sample Acquisition Protocol Can Improve Data Quality and Reduce Inter-Instrument Variability of the Helios Mass Cytometer

The paper describes a modified Helios mass cytometer protocol that improves data quality and reduces inter-instrument variability in multi-center studies.

Dietary intake regulates the circulating inflammatory monocyte pool

This study shows that fasting reduces circulating pro-inflammatory monocytes and their metabolic activity, while preserving their emergency mobilization during acute inflammation.

Single-cell analysis of Crohn’s disease lesions identifies a pathogenic cellular module associated with resistance to anti-TNF therapy