Author

T. Persse

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Cancer Biology· 1

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Assay:bulk RNA-seq· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

A. Bankhead· 1 shared B. Hanratty· 1 shared c. Morrissey· 1 shared C. Pritchard· 1 shared D. Li· 1 shared D. Rudoy· 1 shared D. Wilson· 1 shared E. Corey· 1 shared

Activity by Year

2024-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperCancer Biology

A. Bankhead

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1 paper

Recent·Most cited

Molecular consequences of acute versus chronic CDK12 loss in prostate carcinoma nominates distinct therapeutic strategies

S. Frank, T. Persse, I. M. Coleman, A. Bankhead, D. Li, N. DeSarkar, D. Wilson, D. Rudoy, M. Vashisth, P. Galipeau, M. Yang, B. Hanratty, R. Dumpit, c. Morrissey, E. Corey, , P. S. Nelson

This study shows that acute CDK12 loss in prostate cancer causes HR deficiency via polyadenylation, but chronic loss leads to adaptation, making PARP inhibitors ineffective and suggesting CDK13 targeting as a new therapeutic approach.

bioRxiv · Jul 16, 2024 · PreprintCancer Biology