D. Wilson

Molecular consequences of acute versus chronic CDK12 loss in prostate carcinoma nominates distinct therapeutic strategies

This study shows that acute CDK12 loss in prostate cancer causes HR deficiency via polyadenylation, but chronic loss leads to adaptation, making PARP inhibitors ineffective and suggesting CDK13 targeting as a new therapeutic approach.

Effect of antiretroviral protease inhibitors on Plasmodium falciparum erythrocyte egress and invasion

This study investigates the effect of antiretroviral protease inhibitors on Plasmodium falciparum egress and invasion, finding limited impact despite their antiplasmodial activity.

A missense mutation in zinc finger homeobox-3 (ZFHX3) impedes growth and alters metabolism and hypothalamic gene expression in mice.

This study shows that a ZFHX3 mutation in mice reduces body weight, alters metabolism, and changes hypothalamic gene expression related to growth and energy balance.

WITHDRAWAL: Extinction risk modeling predicts range-wide differences of climate change impact on Karner blue butterfly

The paper withdraws a manuscript due to lack of required review and approval process.

SARS-CoV2 variant-specific replicating RNA vaccines protect from disease and pathology and reduce viral shedding following challenge with heterologous SARS-CoV2 variants of concern

This study evaluates a replicating RNA vaccine against SARS-CoV-2 variants, showing protection from disease and reduced viral shedding after heterologous challenge.

Defining Cardiac Cell Populations and Relative Cellular Composition of the Early Fetal Human Heart

This study identifies and quantifies cardiac cell populations in the early fetal human heart using immunohistochemistry, flow cytometry, and RT-PCR, revealing distinct marker profiles and proportions compared to adult hearts.

In vivo modelling of patient genetic heterogeneity identifies concurrent Wnt and PI3K activity as a potent driver of invasive cholangiocarcinoma growth.

This study identifies concurrent Wnt and PI3K activity as drivers of invasive cholangiocarcinoma growth and shows that their co-inhibition slows tumor growth in vivo.

Signalome-wide assessment of erythrocyte response to Plasmodium reveals novel targets for host-directed antimalarial intervention

The paper assesses host erythrocyte signaling during Plasmodium infection and identifies c-MET and B-Raf as potential targets for antimalarial intervention.

The alarmone (p)ppGpp is part of the heat shock response of Bacillus subtilis

This study shows that (p)ppGpp, a bacterial alarmone, mediates the heat shock response in B. subtilis by reducing translation and enhancing stress tolerance.

The genomic basis of evolved virus resistance is dependent on environmental resources

This study identifies genomic mechanisms of virus resistance in a lepidopteran pest, showing that resistance evolves differently under varying nutritional conditions and is linked to metabolic, immune, or cytoskeleton pathways.

Probing the evolutionary robustness of two repurposed drugs targeting iron uptake in Pseudomonas aeruginosa

This study evaluates the evolutionary robustness of two drugs targeting iron uptake in Pseudomonas aeruginosa, finding that resistance development varies between the drugs.

Evaluation of tuberculosis treatment response with serial C-reactive protein measurements

This study evaluates CRP as a biomarker for tuberculosis treatment response, finding significant reductions in CRP and its predictive value for adverse outcomes.

Trends in CRP, D-dimer and fibrinogen during therapy for HIV associated multidrug resistant tuberculosis

This study tracks CRP, D-dimer, and fibrinogen levels in HIV-positive patients with MDR-TB to assess treatment response and mortality risk.

The Distribution of Bacterial Doubling Times in the Wild

The paper estimates bacterial doubling times in the wild by comparing mutation rates and accumulation rates across species, finding wild doubling times are much longer and vary widely.