Author

H. Strahl

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 11

Signature Assays, Organisms & Methods

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Approach:experimental assay· 9 Organism:bacteria (other)· 8 Assay:proteomics· 6 Research Focus:cell signaling & trafficking· 5 Research Focus:host-pathogen & immune response· 5 Research Focus:cell type annotation· 3 Research Focus:chromatin & epigenetic regulation· 2 Organism:E. coli· 2

Frequent Co-Authors

J. A. Buttress· 3 shared C. K. Saha· 2 shared G. C. Atkinson· 2 shared G. Mariano· 2 shared S. Jimmy· 2 shared S. R. A. Oliveira· 2 shared T. Kurata· 2 shared T. Palmer· 2 shared

Activity by Year

2017-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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3 shared papersMicrobiology

J. A. Buttress

Mutual co-authors in cluster

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11 papers

Recent·Most cited

Shield co-opts an RmuC domain to mediate phage defence across Pseudomonas species.

E. Macdonald, H. Strahl, T. R. Blower, T. Palmer, G. Mariano

This paper identifies and characterizes a novel anti-phage system called Shield in Pseudomonas species, showing it can mediate bacterial immunity against phages through a membrane-bound protein with an RmuC domain.

PLOS Genetics · Jun 5, 2023Peer-reviewedMicrobiology

Molecular motor tug-of-war regulates elongasome cell wall synthesis dynamics in Bacillus subtilis

S. Middlemiss, M. Blandenet, D. M. Roberts, A. McMahon, J. Grimshaw, J. M. Edwards, Z. Sun, K. D. Whitley, T. Blu, H. Strahl, S. Holden

This study tracks elongasome dynamics in Bacillus subtilis using single molecule fluorescence microscopy and shows molecular motor tug-of-war regulates processivity and termination events.

bioRxiv · May 10, 2023 · PreprintMicrobiology

Lipoteichoic acid biosynthesis by Staphylococcus aureus is controlled by the MspA protein through competitive interference.

D. Bonini, S. Duggan, A. A. Alnahari, T. Brignoli, H. Strahl, R. C. Massey

This study shows that MspA regulates lipoteichoic acid levels in S. aureus by interfering with LtaA-LtaS interactions, affecting cell size and pathogenicity.

bioRxiv · May 9, 2023 · PreprintMicrobiology

A guide for membrane potential measurements in Gram-negative bacteria using voltage-sensitive dyes

J. A. Buttress, M. Halte, J. D. te Winkel, M. Erhardt, P. F. Popp, H. Strahl

This paper provides guidance on measuring membrane potential in Gram-negative bacteria using DiSC3(5) dyes, addressing challenges posed by the outer membrane and buffer conditions.

bioRxiv · Apr 30, 2022Microbiology

Low membrane fluidity triggers lipid phase separation and protein segregation in vivo

M. Gorhbandt, A. Lipski, J. W. Grimshaw, J. A. Buttress, Z. Baig, B. Herkenhoff, S. Walter, R. Kurre, G. Deckers-Hebestreit, H. Strahl

The paper shows that low membrane fluidity in bacteria triggers lipid phase separation and protein segregation without disrupting membrane function.

bioRxiv · Sep 22, 2021Microbiology

Panacea: a hyperpromiscuous antitoxin protein domain for the neutralisation of diverse toxin domains

T. Kurata, C. K. Saha, J. A. Buttress, T. Mets, T. Brodiazhenko, K. J. Turnbull, O. F. Awoyomi, S. R. A. Oliveira, S. Jimmy, K. Ernits, M. Delannoy, K. Persson, T. Tenson, H. Strahl, V. Hauryliuk, G. C. Atkinson

The paper identifies and validates a hyperpromiscuous antitoxin domain, Panacea, capable of neutralizing diverse toxin domains across microbial and bacteriophage TA systems.

bioRxiv · May 7, 2021Microbiology

A membrane-depolarising toxin substrate of the Staphylococcus aureus Type VII secretion system mediates intra-species competition

F. R. Ulhuq, M. C. Gomes, G. Duggan, M. Guo, C. Mendonca, G. Buchanan, J. D. Chalmers, Z. Cao, H. Kneuper, S. Murdoch, S. Thomson, H. Strahl, M. Trost, S. Mostowy, T. Palmer

This paper identifies TspA as a new T7SS substrate in S. aureus, showing it mediates intra-species competition by membrane depolarization and growth inhibition in vivo.

bioRxiv · Jun 2, 2020 · PreprintMicrobiology

A widespread toxin-antitoxin system exploiting growth control via alarmone signalling

S. Jimmy, C. K. Saha, C. G. Stavropoulos, S. R. A. Oliveira, T. Kurata, A. Koh, A. Cepauskas, H. Takada, T. Tenson, H. Strahl, A. Garcia-Pino, V. Hauryliuk, G. C. Atkinson

The paper identifies toxin-antitoxin systems in bacteria using alarmone signalling, showing how SASs function as toxins and their antitoxins counteract them.

bioRxiv · Sep 4, 2019 · PreprintMicrobiology

A new family of Type VI secretion system-delivered effector proteins displays ion-selective pore-forming activity

G. Mariano, K. Trunk, D. J. Williams, L. Monlezun, H. Strahl, S. J. Pitt, S. J. Coulthurst

The paper identifies Ssp6 as an ion-selective pore-forming toxin delivered by the T6SS of Serratia marcescens, showing it causes membrane depolarization and increased permeability.

bioRxiv · Jun 20, 2019 · PreprintMicrobiology

The Gram-positive model organism Bacillus subtilis does not form microscopically detectable cardiolipin-specific lipid domains

A.-R. Pogmore, K. H. Seistrup, H. Strahl

This study shows that Bacillus subtilis does not form detectable cardiolipin-specific lipid domains and that NAO is not a specific stain for cardiolipin in this organism.

bioRxiv · Jan 28, 2018Microbiology

Membrane curvature and the Tol-Pal complex determine polar localization of the chemoreceptor Tar in E. coli

T. Saaki, H. Strahl, L. W. Hamoen

This study identifies membrane curvature and Tol-Pal complex interaction as key factors for polar localization of the chemoreceptor Tar in E. coli.

bioRxiv · Nov 1, 2017Microbiology