BioengineeringbioRxiv
Central Nervous System Delivery and Biodistribution Analysis of an Antibody-Enzyme Fusion for the Treatment of Lafora Disease
G. L. Austin, Z. R. Simmons, J. E. Klier…·M. S. Gentry
This study evaluates the cerebral delivery and biodistribution of VAL-0417, an antibody-enzyme fusion for Lafora disease, showing intracerebroventricular administration is most effective.
DOI 10.1021/acs.molpharmaceut.9b00396