Cardiac Specific Overexpression of Transcription Factor EB (TFEB) in Normal Hearts Induces Pathologic Cardiac Hypertrophy and Lethal Cardiomyopathy
H. C. Kenny, E. T. Weatherford, G. V. Collins, C. Allamargot, T. Gesalla, K. Zimmerman, H. Goel, J. M. McLendon, D.-F. Dai, T. Romac, J. Streeter, D. Abhinav, R. O. Pereira, J. Sharafuddin, L.-S. Song, E. D. Abel
This study shows that cardiac-specific overexpression of TFEB leads to pathologic hypertrophy and lethal cardiomyopathy through mitochondrial dysfunction and fibrosis.
bioRxiv · Feb 16, 2021 · PreprintCell Biology