Author

D.-F. Dai

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 3 Pathology· 2 Physiology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 8 Organism:mouse· 7 Research Focus:cell type annotation· 6 Research Focus:metabolism & bioenergetics· 4 Research Focus:cell signaling & trafficking· 3 Organism:human· 3 Assay:imaging· 3 Assay:bulk RNA-seq· 2

Frequent Co-Authors

A. G. Marshall· 4 shared E. Garza-Lopez· 4 shared H. K. Beasley· 4 shared K. Neikirk· 4 shared L. Vang· 4 shared N. Daneshgar· 4 shared Z. Vue· 4 shared A. Crabtree· 3 shared

Activity by Year

2021-2024 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersBiophysics

A. G. Marshall

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Transport activity regulates mitochondrial bioenergetics and biogenesis in renal tubules

C.-J. Cheng, J. M. Nizar, D.-F. Dai, C.-L. Huang

This paper develops an extracellular flux analysis to study mitochondrial respiration and energy metabolism in isolated renal tubules, showing transport activity regulates mitochondrial bioenergetics and biogenesis.

bioRxiv · Feb 4, 2024Physiology

Human Heart Failure Alters Mitochondria and Fiber 3D Structure Triggering Metabolic Shifts

Z. Vue, P. T. Ajayi, K. Neikirk, A. Murphy, P. Prasad, B. C. Jenkins, L. Vang, E. Garza-Lopez, M. Mungai, A. G. Marshall, H. K. Beasley, M. Killion, R. Parker, J. Anukodem, K. Lavine, , A. Hinton

This study identifies structural and metabolic changes in human heart failure using SBF-SEM and metabolomic analyses.

bioRxiv · Nov 28, 2023 · PreprintPhysiology

Cardiovascular Hemodynamics in Mice with Tumor Necrosis Factor Receptor - Associated Factor 2 Mediated Cytoprotection in the Heart

A. G. Marshall, K. Neikirk, Z. Vue, H. K. Beasley, E. Garza-Lopez, L. Vang, T. Barongan, Z. Evans, A. Crabtree, E. Spencer, J. Anudokem, R. Parker, J. Davis, D. Stephens, S. Damo, , A. K. Reddy

This study evaluates global cardiac function in mice with cardiac-restricted TRAF2 overexpression, finding diminished cardiac function despite reported tolerance to ischemic insults.

bioRxiv · Sep 3, 2022Biophysics

Three-Dimensional Mitochondria Reconstructions of Murine Cardiac Muscle Changes in Size Across Aging

Z. Vue, K. Neikirk, L. Vang, E. Garza-Lopez, T. A. Christensen, J.-q. Shao, J. Lam, H. K. Beasley, A. G. Marshall, A. Crabtree, J. Anudokem, B. Rodriguez, B. Kirk, S. Bacevac, T. Barongan, , A. Hinton

This study uses 3D imaging to show that mitochondria in aging mouse hearts lose cristae structure and volume, similar to mutations in MICOS complex genes.

bioRxiv · Apr 23, 2022Biophysics

3D Reconstruction of Murine Mitochondria Exhibits Changes in Structure Across Aging Linked to the MICOS Complex

Z. Vue, E. Garza-Lopez, K. Neikirk, P. Katti, L. Vang, H. K. Beasley, J.-q. Shao, A. G. Marshall, A. Crabtree, A. C. Murphy, B. C. Jenkins, P. Prasad, C. S. Evans, B. T. Taylor, M. Mungai, , Murray

This study examines age-related changes in mitochondrial 3D structure in mouse muscle and heart tissues, linking these changes to the MICOS complex and metabolic alterations.

bioRxiv · Mar 22, 2022Biophysics

Metabolic rescue ameliorates mitochondrial encephalo-cardiomyopathy in murine and human iPSC models of Leigh syndrome

J.-Y. Yoon, N. Daneshgar, Y. Chu, B. Chen, M. Hefti, K. Irani, L.-S. Song, C. Brenner, E. D. Abel, B. London, D.-F. Dai

This study shows that metabolic rescue with nicotinamide riboside improves mitochondrial encephalo-cardiomyopathy in mouse and human iPSC models of Leigh syndrome.

bioRxiv · Jan 4, 2022Pathology

Metabolic Derangement in Polycystic Kidney Disease Mouse Models Is Ameliorated by Mitochondrial-Targeted Antioxidants

N. Daneshgar, A. W. Baguley, P.-I. Liang, F. Wu, Y. Chu, M. T. Kinter, G. A. Benavides, M. S. Johnson, V. Darley-Usmar, J. Zhang, K.-S. Chan, D.-F. Dai

This study shows mitochondrial-targeted antioxidants reduce oxidative stress and metabolic issues in PKD mouse models, improving disease progression and restoring metabolic pathways.

bioRxiv · Sep 15, 2021 · PreprintPathology

Cardiac Specific Overexpression of Transcription Factor EB (TFEB) in Normal Hearts Induces Pathologic Cardiac Hypertrophy and Lethal Cardiomyopathy

H. C. Kenny, E. T. Weatherford, G. V. Collins, C. Allamargot, T. Gesalla, K. Zimmerman, H. Goel, J. M. McLendon, D.-F. Dai, T. Romac, J. Streeter, D. Abhinav, R. O. Pereira, J. Sharafuddin, L.-S. Song, E. D. Abel

This study shows that cardiac-specific overexpression of TFEB leads to pathologic hypertrophy and lethal cardiomyopathy through mitochondrial dysfunction and fibrosis.

bioRxiv · Feb 16, 2021 · PreprintCell Biology