Pharmacology & ToxicologybioRxiv
Structural analysis of the macrocyclic inhibitor BI-4020 binding to EGFR kinase
T. S. Beyett, J. K. Rana, I. K. Schaeffner…·M. J. Eck
The paper analyzes the structural basis of BI-4020's selectivity and potency against mutant EGFR by combining biochemical assays and X-ray crystallography.
DOI 10.1002/cmdc.202300343