Notch1 regulates breast cancer stem cell function via a non-canonical cleavage-independent pathway
L. Sui, S. Wang, R. K. Rodriguez, D. Sim, N. Bhattacharya, A. L. Blois, T. Schlaeger, S. Chen, S. Aziz, M. S. Rogers, D. R. Bielenberg, L. A. Akslen, R. S. Watnick
This study identifies a non-canonical Notch1 pathway that represses SIRT1 to drive tumor initiation and chemoresistance in breast cancer stem cells.
bioRxiv · Feb 28, 2020 · PreprintCancer Biology