Author

D. Sim

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Bioengineering· 1 Evolutionary Biology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:cancer & tumor microenvironment· 2 Organism:human· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

D. R. Bielenberg· 2 shared L. A. Akslen· 2 shared L. Sui· 2 shared M. S. Rogers· 2 shared R. S. Watnick· 2 shared S. Aziz· 2 shared S. Wang· 2 shared A. Borretzen· 1 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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2 shared papersCancer Biology

D. R. Bielenberg

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Targeting NGF but not VEGF or BDNF signaling reduces endometriosis-associated pain in mice

T. H. Zaninelli, V. Fattori, O. K. Heintz, K. R. Wright, P. R. Bennallack, D. Sim, H. Bukhari, K. L. Terry, A. F. Vitonis, S. A. Missmer, A. C. Andrello, R. Anchan, S. K. Godin, D. Bree, W. A. Verri, M. S. Rogers

This study shows that blocking NGF-TrkA signaling reduces endometriosis-associated pain in mice, while blocking VEGF-VEGFR1 or BDNF-TrkB does not.

bioRxiv · Dec 5, 2023 · PreprintPharmacology & Toxicology

PRSS2 stimulates tumor growth by remodeling the TME via repression of Tsp1

L. Sui, S. Wang, D. Ganguly, T. El Rayes, C. Askeland, A. Borretzen, K. Zhou, D. Sim, O. J. Halvorsen, G. Knutsvik, S. Aziz, S. Haukaas, W. D. Foulkes, D. R. Bielenberg, A. Ziemys, , R. S. Watnick

This study identifies PRSS2 as a factor that represses Tsp-1 in the tumor microenvironment by binding to LRP1, promoting tumor growth.

bioRxiv · Mar 23, 2021 · PreprintCancer Biology

Reverse Pneumatic Artificial Muscles for Application in Low-Cost Artificial Respirators

S. Mirvakili, D. Sim, R. Langer

This paper presents a low-cost, portable mechanical ventilator design using reverse pneumatic artificial muscles for volume-controlled ventilation in emergencies.

bioRxiv · May 20, 2020 · PreprintBioengineering

Notch1 regulates breast cancer stem cell function via a non-canonical cleavage-independent pathway

L. Sui, S. Wang, R. K. Rodriguez, D. Sim, N. Bhattacharya, A. L. Blois, T. Schlaeger, S. Chen, S. Aziz, M. S. Rogers, D. R. Bielenberg, L. A. Akslen, R. S. Watnick

This study identifies a non-canonical Notch1 pathway that represses SIRT1 to drive tumor initiation and chemoresistance in breast cancer stem cells.

bioRxiv · Feb 28, 2020 · PreprintCancer Biology

The effect of drug dose and timing of treatment on the emergence of drug resistance in vivo in a malaria model

M. M. Acosta, D. Sim, J. T. Bram, A. F. Read

This study investigates how drug dose and timing affect resistance emergence in a malaria model, finding that higher doses can increase resistance and timing impacts resistance risk non-linearly.

bioRxiv · Jan 27, 2020Evolutionary Biology