Author
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
3 papers
Recent·Most cited
D. J. Kauert, J. Madariaga Marcos, M. Rutkauskas…·R. Seidel
This paper uses ultrafast DNA unwinding experiments to study the energy landscape of R-loop formation by the Cascade complex, revealing a downhill bias followed by an uphill bias and showing base flips and mismatches modulate the landscape.
P. Aldag, M. Rutkauskas, J. Madariaga-Marcos…·R. Seidel
This study investigates how the Type I-E CRISPR-Cas Cascade complex searches and recognizes DNA targets, showing that recognition probabilities are low and increased by DNA supercoiling and limited 1D diffusion.
M. Rutkauskas, I. Songailiene, P. Irmisch…·R. Seidel
The paper develops a quantitative model to predict CRISPR-Cas Cascade off-target recognition dynamics using single-molecule experiments and shows it accurately captures target recognition with mutations.