Variable Induction of Pro-inflammatory Cytokines by Commercial SARS CoV-2 Spike Protein Reagents: Potential Impacts of LPS on In Vitro Modeling and Pathogenic Mechanisms In Vivo
W. Ouyang, T. Xie, H. Fang, C. Gao, T. Stantchev, K. A. Clouse, K. Yuan, T. Ju, D. M. Frucht
This study shows that commercial SARS CoV-2 spike protein reagents vary in their ability to induce pro-inflammatory cytokines, likely due to contamination with endotoxin (LPS).
bioRxiv · May 26, 2021Microbiology