K. Yuan

This study identifies O-GlcNAcylation of mushroom body ribosomal subunits as essential for olfactory learning in Drosophila, showing that reducing O-GlcNAcylation impairs learning.

The paper reveals a fully-connected corticothalamic architecture in the auditory system, showing L5 neurons project broadly to thalamic modules, challenging traditional hierarchical models.

This paper introduces a geometric descriptor based on integrated Gaussian curvature to predict surgical success in aortic dissections by analyzing shape changes.

This study examines ACE-2 expression and shedding in placental tissues and maternal serum during SARS-CoV-2 infection in pregnancy, finding increased soluble ACE-2 in third-trimester infections.

This study identifies increased RNA polymerase II pausing as a mechanism of acquired radiotherapy resistance in cancer cells and suggests CDK7 inhibitors as a potential therapeutic strategy.

This study shows ARID1A loss activates HERVH, which promotes tumor growth by modulating BRD4-dependent transcription in colorectal cancer.

This study shows that BCL6 helps cancer cells survive genotoxic stress by repressing PTEN and enhancing interferon responses, suggesting BCL6 inhibition could improve cancer treatment.

This study shows that commercial SARS CoV-2 spike protein reagents vary in their ability to induce pro-inflammatory cytokines, likely due to contamination with endotoxin (LPS).

This study characterizes intra-tumor heterogeneity across 2,658 human cancer genomes, identifying subclonal mutations and evolutionary patterns across 38 cancer types.

The paper investigates the origin and timing of Denisovan introgression into Tibetans at the EPAS1 locus, finding an East Asian-specific introgression event around 43,000 years ago followed by selection 12,000 years ago.

The paper develops a shrimp aquaculture ecosystem using predatory fish to control WSSV transmission, effectively preventing outbreaks.

SVclone infers cancer cell fractions of structural variant breakpoints from whole-genome sequencing data and identifies subclonal copy-number neutral rearrangements linked to decreased survival in certain cancers.

This study uses gold nanobipyramids as OCT contrast agents to visualize multiplexed lymphatic flows in live mice, showing distinct drainage patterns from a melanoma tumor to sentinel lymph nodes.

This study uses whole-genome sequencing of cancer samples to reconstruct the evolutionary history of 39 cancer types, identifying early and late-stage mutational patterns and driver genes.

BaalChIP corrects allele-specific ChIP-seq analysis for copy number variation in cancer genomes, improving detection of regulatory variants.

This study introduces iMAAPs, a method to infer multiple-wave population admixture by modeling ALD decay with polynomial functions, showing improved performance over existing methods.