C. Gao

Lipid droplets restrict phagosome formation during Candida challenge

This study shows that lipid droplets restrict phagosome formation in macrophages during Candida infection, protecting cells from death and offering a potential drug target.

Diversity and ecological potentials of viral assemblages from the seamount sediments of the Northwest Pacific Ocean

The paper analyzes viral diversity in seamount sediments, identifying 78,069 vOTUs and 16 vAMGs, suggesting ecological roles in biogeochemical cycles.

Relieving the transfusion tissue traffic jam: a network model of radial transport in conifer needles

The paper develops a network model to show how transfusion tissue in conifer needles facilitates radial transport of sugar and water by separating their pathways, mitigating flow bottlenecks.

Balance Between EGF/STAT1 and IFNγ/NRF2 Signaling Controls ECM1 Expression and Determines Hepatic Homeostasis versus Chronic Liver Disease

This study identifies EGF/STAT1 and IFNγ/NRF2 signaling pathways regulating ECM1 expression, showing their role in maintaining liver homeostasis versus promoting chronic liver disease.

Senolytic Treatment for Low Back Pain.

Senolytic drugs reduce low back pain by eliminating senescent cells and decreasing inflammatory factors in the intervertebral disc and spinal cord.

Targeting transcription factors through an IMiD independent zinc finger domain

This study identifies a new IMiD-independent drug targeting SALL4's ZFC4 domain, leading to significant tumor growth inhibition in vivo.

Potential clinical value and influence of conductivity in conductive cardiac patches for reducing post-MI arrythmia risks

This study evaluates the clinical value of conductive cardiac patches by testing different conductivities and shows that higher conductivity reduces arrhythmia risks in post-MI hearts.

DNA sensor ABCF1 phase separates with cccDNA to inhibit HBV replication

This study identifies ABCF1 as a host protein that interacts with cccDNA, forming phase-separated condensates to suppress HBV replication through innate immune activation and transcription inhibition.

ECM1 Attenuates Hepatic Fibrosis by Interfering with Mediators of Latent TGF-β1 Activation

This study shows ECM1 prevents hepatic fibrosis by inhibiting TGF-β1 activation, with implications for developing safe anti-fibrotic therapies.

Systematic benchmarking of imaging spatial transcriptomics platforms in FFPE tissues

This study benchmarks three imaging spatial transcriptomics platforms on FFPE tissues, finding 10x Xenium has higher transcript counts without sacrificing specificity, while all platforms align with RNA-seq data but vary in performance metrics.

The structural OFF and ON states of myosin can be decoupled from the biochemical super-relaxed and disordered-relaxed states.

This study decouples structural OFF/ON states from biochemical SRX/DRX states in myosin using X-ray diffraction and ATP assays in porcine myocardium.

Characterizing Low-cost Registration for Photographic Images to Computed Tomography

The paper compares low-cost photographic imaging methods with a 3-D camera for registering photographic images to CT scans, finding iPhone imaging has lower landmark error in some cases.

Recognition of highly branched N-glycans of the porcine whipworm by the immune system

The paper identifies N-glycans from the porcine whipworm Trichuris suis that are recognized by the immune system and exhibit species-specific features.

Perturbations of glutathione and sphingosine metabolites in Port Wine Birthmark patient-derived induced pluripotent stem cells

This study identifies metabolic perturbations in PWB-derived iPSCs, showing upregulated glutathione and downregulated sphingolipid metabolism, which may contribute to laser resistance in PWB vasculature.

Dissociable encoding of motivated behavior by parallel thalamo-striatal projections

This study identifies two distinct PVT neuronal populations that encode different aspects of motivated behavior in mice during a reward foraging task.

SALLB not targeted by IMiDs is important for maintenance of liver cancer cells

The paper identifies a compound that degrades both SALL4 isoforms, overcoming IMiD limitations in liver cancer treatment.

Supporting materials: Endothelial cells differentiated from patient dermal fibroblast-derived induced pluripotent stem cells resemble vascular malformations of Port Wine Birthmark

This study generates iPSCs from PWB fibroblasts and differentiates them into ECs that recapitulate disease phenotypes, identifying dysregulated pathways and genes involved in vascular malformations.

Persistence of intact HIV-1 proviruses in the brain during antiretroviral therapy

The paper examines HIV-1 provirus persistence in CNS tissues during ART by analyzing multiple anatomical compartments in treated individuals.

Comprehensive Characterization and Global Transcriptome Analyses of Human Fetal Liver Terminal Erythropoiesis

This study characterizes human fetal liver terminal erythropoiesis through RNA sequencing of primary and cultured erythroblasts and immortalized cell lines, revealing gene expression patterns and pathway changes associated with enucleation.

Platelet-Localized ST6Gal1 Does Not Impact IgG Sialylation

This study investigates whether platelet-localized ST6Gal1 affects IgG sialylation and finds no significant impact.

Alternative splicing of a potato disease resistance gene maintains homeostasis between development and immunity

The paper shows that the potato resistance gene RB uses alternative splicing to balance growth and immunity, with the pathogen effector IPI-O1 promoting splicing to enhance immunity.

Widespread readthrough events in plants reveal unprecedented plasticity of stop codons

The paper identifies widespread stop codon readthrough events in plants and reveals the plasticity of stop codons in encoding amino acids.

Epigenetic modifications mediate cultivar-specific root development and metabolic adaptation to nitrogen availability in wheat

A cleaved METTL3 potentiates the METTL3-WTAP interaction and breast cancer progression

This study identifies a cleaved form of METTL3, METTL3a, which enhances METTL3-WTAP interaction and promotes breast cancer progression through m6A methylation and mTOR activation.

ABI5-FLZ13 Module Transcriptionally Represses Growth-related Genes to Delay Seed Germination in Response to ABA

This study identifies FLZ13 as an ABI5-interacting protein that co-represses growth-related genes to delay seed germination in response to ABA.

Danicamtiv increases myosin recruitment and alters the chemomechanical cross bridge cycle in cardiac muscle

This study investigates how Danicamtiv increases force and alters cardiac muscle contraction kinetics by modulating myosin function and cross bridge dynamics in cardiac tissue.

Heterogeneity of Glycan Biomarker Clusters as an Indicator of Recurrence in Pancreatic Cancer

The paper examines glycan biomarker clusters in pancreatic cancer tumors to identify recurrence indicators using spatial analysis of immunofluorescence data.

The SARS-CoV-2 Spike protein induces long-term transcriptional perturbations of mitochondrial metabolic genes, causes cardiac fibrosis, and reduces myocardial contractile in obese mice

This study shows that the SARS-CoV-2 Spike protein causes long-term mitochondrial gene suppression, cardiac fibrosis, and reduced myocardial contractility in obese mice.

Flow-induced mechanical coupling between perinuclear actin cap and nucleus governs spatiotemporal regulation of YAP transport

This study investigates how flow-induced mechanical forces regulate YAP nucleocytoplasmic transport through actin cap formation and nuclear stiffness changes, revealing a unified mechanism linking mechanical stimulation to transcriptional regulation.

Submicron-sized in-situ osmotic pressure sensors for in-vitro applications in biology

The paper develops FRET-based liposomal sensors to measure osmotic pressure in cell cultures, demonstrating their effectiveness in pre-osteoblastic systems.