Cancer BiologybioRxivPreprint
A dietary pan-amino acid dropout screen in vivo reveals a critical role for histidine in T-ALL
Komal Mandleywala, Simona Ulrich, Victoria da Silva-Diz…·Daniel Herranz
This study identifies histidine depletion as an antileukemic strategy in T-ALL by revealing its role in suppressing cholesterol biosynthesis through ribosome stalling and GCN2 activation.
DOI 10.64898/2025.12.21.694897