Systems BiologyeLifePeer-reviewed
Evolutionary druggability: leveraging low-dimensional fitness landscapes towards new metrics for antimicrobial applications
Rafael F. Guerrero, Tandin Dorji, Ra’Mal M. Harris…·C. Brandon Ogbunugafor
The paper introduces two metrics to quantify drug-target interactions across genetic variants and drug panels, and analyzes their interactions in a beta-lactamase and beta-lactam drug system.
2 citations