BiochemistrybioRxivPreprint
Glucose is a ligand-like trigger for secretion of postprandial GLP-1
Chun Mu Li, Mengqi Li, Heng-Ye Yang…·Sheng‐Cai Lin
This study shows glucose directly binds to glucokinase (GK) to trigger GLP-1 secretion in intestinal L cells, independent of ATP levels, and identifies GK and KATP as key players in this process.
DOI 10.64898/2026.01.04.697549