Cancer BiologybioRxivPreprint
Pyruvate Kinase Activity Regulates Cystine Starvation Induced Ferroptosis through Malic Enzyme 1 in Pancreatic Cancer Cells
Elliot Ensink, Tessa Jordan, Hyllana C. D. Medeiros…·Sophia Y. Lunt
This study shows that PKM2 knockout in pancreatic cancer cells increases resistance to cystine starvation-induced ferroptosis by reprogramming glutamine metabolism through ME1 to produce NADPH.
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