Genome-wide screen of cell-cycle regulators in normal and tumor cells identifies a differential response to nucleosome depletion
Maria Sokolova, Mikko Turunen, Oliver Mortusewicz…·Jussi Taipale
The paper identifies CASP8AP2 as a cell-cycle regulator with differential effects on DNA replication in normal and tumor cells, leading to distinct outcomes in S-phase progression and cell survival.