Thomas Helleday

The paper establishes a high-throughput screening dataset of small-molecule inhibitors across nine human DNA glycosylases, identifying previously unreported inhibitors and making data publicly available.

RareFoldGPCR designs peptide agonists using noncanonical amino acids to modulate GPCRs, validated experimentally for functional activity.

This paper designs cyclic peptide agonists for GCGR and GLP1R using EvoBind, achieving dual activation with EC50 values comparable to natural hormones.

This study identifies NUDT15 and NUDT18 as human enzymes that hydrolyze isoprene pyrophosphates, with NUDT18 showing the highest catalytic efficiency for geranyl pyrophosphate.

The paper uses spatial transcriptomics to analyze copy number variations in benign and malignant tissues, revealing clonal patterns and suggesting early cancer evolution mechanisms.

The paper identifies an ATM/Wip1-dependent timer mechanism that determines the minimal duration of DNA-damage-induced cell cycle arrest.