Cell BiologybioRxivPreprint
Phosphorylated ubiquitin is a secondary messenger and an epigenetic mark mediating mitochondria to nucleus signaling
Thomas J. Mercer, Bence Dániel, Craig Fredrickson…·Bariş Bingöl
This study identifies phosphorylated ubiquitin (pS65Ub) as a signaling molecule that mediates mitochondrial-to-nuclear communication by modulating histone ubiquitination and gene expression in Parkinson's disease.
DOI 10.64898/2026.04.24.719390